J. Anim Sci.
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Published online first on November 21, 2008
J. Anim Sci. 1910. doi:10.2527/jas.2008-1330
© 2008 American Society of Animal Science
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Board-Invited Review: Porcine Mucosal Immunity of the Gastrointestinal Tract

T. E. Burkey*, K. A. Skjolaas{dagger} and J. E. Minton{ddagger}

* Department of Animal Science, University of Nebraska, Lincoln 68583 , {dagger} Talecris Biotherapeutics, Research Triangle Park, NC 27709 {ddagger} Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506

tburkey2{at}unl.edu

Abstract

The gastrointestinal tract (GIT) comprises one of the largest immunological organs of the body. The GIT must permit absorption of nutrients while also maintaining the ability to appropriately respond to a diverse milieu of dietary and microbial antigenic components. Because of the diverse population of antigenic components within the GIT, a sophisticated mucosal immune system has evolved that relies on collaboration between the innate and adaptive arms of immunity. The collaborative, mucosal immune effort offers protection from harmful pathogens while also being tolerant of dietary antigens and normal microbial flora. Knowledge with respect to porcine mucosal immunity is important as we strive to understand the interrelationships between GIT physiology, immunology and the resident microbiota. The aim of this review is to provide a descriptive overview of GIT immunity and components of the mucosal immune system and to highlight differences that exist between the porcine species and other mammals.

Key Words: gut-associated lymphoid tissue • intestinal epithelial cells • mucosal immunity • pigs






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