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This Article Full Text (PDF) All Versions of this Article: jas.2008-1187v1 87/13_suppl/10    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bannerman, D. D. Search for Related Content PubMed PubMed Citation Articles by Bannerman, D. D.

Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows

Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705

dbannerm{at}yahoo.com

Abstract

Mastitis is a highly prevalent and costly disease of dairy cows that is commonly caused by intramammary bacterial infection. The innate immune response to bacterial penetration of the mammary gland is evoked within hours of infection and the rapidity and magnitude of this response have been demonstrated to influence the resolution of this disease. Cytokines and other mediators of inflammation are known to play critical roles in the innate immune response to intramammary infection. The objectives of this review are to summarize the current understanding of the cytokine response to intramammary infection, highlight recent findings identifying differences in the cytokine response to various bacterial pathogens, and discuss future research directions that will increase our knowledge of the role of inflammatory mediators in predicting and governing the outcome of mastitis.

Key Words: cytokines • dairy cow • inflammation • innate immunity • mastitis