J. Anim Sci.
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Published online first on October 24, 2008
J. Anim Sci. 1910. doi:10.2527/jas.2008-1127
© 2008 American Society of Animal Science
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Single and joint population analyses of two experimental pig crosses to confirm QTL on SSC6 and LEPR effects on fatness and growth traits

G. Muñoz*, C. Ovilo*, L. Silió*, A. Tomás{dagger}, J. L. Noguera{ddagger} and M. C. Rodríguez*

* Departamento de Mejora Genética Animal, SGIT-INIA, 28040 Madrid, Spain , {dagger} Departament de Ciència Animal i dels Aliments, UAB, 08193 Bellaterra, Spain {ddagger} Àrea de Genètica i Millora Animal, Centre IRTA-Lleida, 25198 Lleida, Spain

gloriammster{at}gmail.com

Abstract

The primary goal of this study was to detect and confirm QTL on pig chromosome 6 (SSC6) for growth and fatness traits in 2 experimental F2 intercrosses: Iberian x Landrace (IB x LR); and Iberian x Meishan (IB x MS), which were used in this study for the first time in a QTL analysis related to productive traits. For this purpose, single and joint population analyses with single and bivariate trait models of both populations were performed. The presence of the SSC6 QTL for backfat thickness (BFT) previously identified in the IB x LR cross was detected in this population with additional molecular information, but also was confirmed in the IB x MS cross. In addition, a QTL affecting live weight (LW) was detected in both crosses in a similar position to the QTL detected for backfat thickness. This is the first study in which a QTL affecting live weight is detected on SSC6 in the IB x LR cross, as well as in the IB x MS resource population. Furthermore, we analyzed a previously described non-synonymous LEPR SNP located in exon 14 (c.2002C>T) for causality with respect to this QTL within both F2 populations. Our results supported the previously reported association between LEPR alleles and backfat thickness in the IB x LR cross, and this association was also confirmed within the IB x MS cross. An association not reported before between LEPR alleles and live weight was identified in both populations.

Key Words: backfat thickness • joint analysis • leptin receptor • live weight • pig • polymorphism






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Copyright © 2008 by the American Society of Animal Science.