HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: jas.2008-0999v1 86/12/3473    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Le Floc’h, N. Articles by Sève, B. Search for Related Content PubMed PubMed Citation Articles by Le Floc’h, N. Articles by Sève, B.

Dietary tryptophan helps preserve tryptophan homeostasis in pigs suffering from lung inflammation

N. Le Floc’h^*,, D. Melchior and B. Sève^*,

^* INRA, UMR1079 SENAH, F-35000 Rennes, France , Agrocampus Rennes, UMR1079, F-35000 Rennes, France Ajinomoto-Eurolysine S.A.S., 153 rue de Courcelles, Paris, France

nathalie.lefloch{at}rennes.inra.fr

Abstract

In pigs, inflammation modifies Trp metabolism and consequently could impact on Trp requirement for growth. In this study, the effects of lung inflammation, induced by the intravenous injection of Complete Freund’s Adjuvant, and dietary Trp content on Trp metabolism and availability were investigated. Two dietary Trp contents, one corresponding to a low (1.5 g of Trp/kg of diet, Basal diet) and the second to an adequate (2 g Trp/kg of diet, TRP diet), were used. Ten blocks of 4 littermate piglets were selected at 40 d of age. Within each block, piglets were randomly assigned to 1 of the 4 experimental treatments: (1) healthy control and Basal diet, (2) inflammation and Basal diet, (3) inflammation and Basal diet + antioxidant, and (4) inflammation and TRP diet. Inflammation induced an increase in indoleamine 2,3 dioxygenase (IDO) activity, an enzyme involved in Trp catabolism, in lung, lymph nodes, heart, and spleen (P < 0.01). Contrary to piglets fed the TRP diet, pigs suffering from inflammation did not maintain their plasma Trp concentrations when they were fed the Basal diet. Furthermore, pigs fed the TRP diet had lower plasma haptoglobin concentrations, IDO activity, and lung weight than those fed the Basal diet, indicating that the inflammatory response was moderated with the higher Trp supply. Antioxidant addition in the Basal diet reduced the effects of inflammation on plasma Trp concentrations and IDO activity. These results indicated that inflammation increases Trp catabolism and thus, may reduce Trp availability for growth.

Key Words: inflammation • metabolism • pig • tryptophan

This article has been cited by other articles:

				N. Le Floc'h, L. LeBellego, J. J. Matte, D. Melchior, and B. Seve The effect of sanitary status degradation and dietary tryptophan content on growth rate and tryptophan metabolism in weaning pigs J Anim Sci, May 1, 2009; 87(5): 1686 - 1694. [Abstract] [Full Text] [PDF]