J. Anim Sci.
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Published online first on August 20, 2007
J. Anim Sci. 1990. doi:10.2527/jas.2007-0456
© 2007 American Society of Animal Science

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J. Anim Sci., doi: 10.2527/jas.2007-0456
©Copyright, 2007, The American Society of Animal Science


ARTICLE

Cellular and molecular regulation of muscle growth and development in meat animals

W. R. Dayton 1* M. E. White 1

1 Department of Animal Science, University of Minnesota, St. Paul, 55108

* To whom correspondence should be addressed. E-mail: wdayton{at}umn.edu.


   Abstract

Although in vivo and in vitro studies have established that anabolic steroids, transforming growth factor-{beta} (TGF-{beta}), and myostatin affect muscle growth in meat-producing animals, their mechanisms of action are not completely understood. Anabolic steroids have been widely used as growth promoters in feedlot cattle for over 50 yr. A growing body of evidence suggests that increased muscle levels of IGF-I and increased muscle satellite cell numbers play a role in anabolic steroid enhanced muscle growth. In contrast to anabolic steroids, the members of the TGF-{beta}/myostatin family suppress muscle growth in vivo and suppress both proliferation and differentiation of cultured myogenic cells. Recent evidence suggests that IGFBP-3 and -5 play a role in mediating the proliferation-suppressing actions of both TGF-{beta} and myostatin on cultured myogenic cells. Consequently, this review will focus on the roles of IGF-I and IGFBP in the cellular and molecular mechanisms of action of anabolic steroids and TGF-{beta}/myostatin, respectively.

Key Words: muscle, Anabolic steroid, Myostatin, Insulin-like growth factor-I, Insulin-like growth factor binding protein, Transforming growth factor-beta







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Copyright © 2007 by the American Society of Animal Science.