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1 Department of Biochemistry and Nutrition, Faculty of Agricultural, Food Environmental Quality Sciences, The Hebrew University, Rehovot, Israel
2 Institute of Animal Science, the Volcani Center, Bet Dagan 50250, Israel
* To whom correspondence should be addressed. E-mail: ornanme{at}agri.huji.ac.il.
| Abstract |
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Vertebrate long bones are formed by endochondral ossification, a process accompanied by changes in extracellular matrix synthesis and remodeling, performed mainly by the matrix metalloproteinases (MMP). The temporal/spatial expression patterns of five members of the MMP family known to be important for endochondral ossification were studied, for the first time, in the turkey growth plate during embryonic and juvenile stages. The expression of MMP-2 was detected in the proliferative zone, MMP-3 and MMP-9 in cells lining the blood vessels, so was MMP-13 which was also detected in hypertrophic chondrocytes. MMP-16 expression was detected in the reserve zone of the growth plate. These results present a detailed survey of turkey MMP, serving as a data source (atlas) for further studies in this subject.
Key Words: Endochondral ossification, growth-plate, matrix metalloproteinase, turkey
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