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This Article Full Text (PDF) All Versions of this Article: jas..2008-1004v1 87/3/1042    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mashiko, T. Articles by Katoh, K. Search for Related Content PubMed PubMed Citation Articles by Mashiko, T. Articles by Katoh, K.

Effects of dietary uridine 5’-monophosphate on immune responses in newborn calves

T. Mashiko^* , S. Nagafuchi, M. Kanbe, Y. Obara^*, Y. Hagawa, T. Takahashi and K. Katoh^#

^* Mito Research Center, Meiji Feed Co., Wakamiya, Higashi-Ibaraki, Ibaraki, 311-3123, Japan , Department of Research and Development, Meiji Feed Co., Midori, Sumida-ku, Tokyo, 130-0021, Japan , Department of Sales and Research, Meiji Feed Co., Midori, Sumida-ku, Tokyo, 130-0021, Japan , Food Science Institute, Division of Research and Development, Meiji Dairies Co., Naruda, Odawara, Kanagawa, 250-0862, Japan ^# Department of Animal Physiology, Graduate School of Agricultural Science, Tohoku University, Amamiyamachi, Aoba-ku, Sendai, 981-8555, Japan

t.mashiko{at}meijifeed.co.jp

Abstract

When compared to normal milk, bovine colostrum contains a large amount of uridine 5’-monophosphate (UMP) and its derivatives. In the present study, we carried out 2 experiments to determine the effects of dietary UMP (2 g/d) on the immune status of newborn calves. In Exp. 1, newborn Holstein bull calves were fed milk replacer alone (control group) or milk replacer supplemented with UMP (UMP group) from d 4 to 10 after birth. Increase in interferon- (IFN-) concentration by peripheral blood mononuclear cells (PBMC) on d 24 tended to be greater in the UMP group than in the control group (P = 0.06). The immunoglobulin A concentration of the ileal mucosa was greater in the UMP group than in the control group (P < 0.05), although there was no difference between groups in the jejunal mucosa. In Exp. 2, newborn Holstein bull calves were fed milk replacer alone (control group) and milk replacer supplemented with UMP (UMP group) from d 4 to 56 after birth. The proliferation of PBMC was greater in the UMP group than in the control group on d 14, 28, and 42 (P < 0.01). Increase in IFN- concentration by PBMC was greater in the UMP group than in the control group on d 28 and 42 (P < 0.05). From these results, we conclude that dietary UMP affects the immune responses of newborn calves.

Key Words: interferon- • mucosal immunoglobulin A • peripheral blood mononuclear cells proliferation • uridine 5’-monophosphate