HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: jas.2006-773v1 86/1/197    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Juniper, D. T. Articles by Bertin, G. Search for Related Content PubMed PubMed Citation Articles by Juniper, D. T. Articles by Bertin, G.

Tolerance of ruminant animals to high dose in-feed administration of a selenium-enriched yeast¹

D. T. Juniper^*,2, R. H. Phipps^*, D. I. Givens^*, A. K. Jones^*, C. Green^* and G. Bertin

^* Animal Science Research Group, School of Agriculture, Policy and Development University of Reading, Earley Gate, Reading RG6 6AR, UK; and ALLTECH France, EU Regulatory Affairs Department, 14 Place Marie-Jeanne Bassot, 92300 Lavallois-Perret, France

² Corresponding author: d.t.juniper{at}reading.ac.uk

The objective of the study was to determine if there were adverse effects on animal health and performance when a range of ruminant animal species were fed at least 10 times the maximum permitted European Union (EU) Se dietary inclusion rate (0.568 mg of Se/kg of DM) in the form of Se-enriched yeast (SY) derived from a specific strain of Saccharomyces cerevisiae, CNCM I-3060. In a series of studies, dairy cows, beef cattle, calves, and lambs were offered a control diet that contained no Se supplement or a treatment diet that contained the same basal feed ingredients plus a SY supplement that increased total dietary Se from 0.15 to 6.25, 0.20 to 6.74, 0.15 to 5.86, and 0.14 to 6.63 mg of Se/kg of DM, respectively. The inclusion of the SY supplement increased (P < 0.001) whole-blood Se concentrations, reaching maximum mean values of 716, 1,505, 1,377, and 724 ng of Se/mL for dairy cattle, beef cattle, calves, and lambs, respectively. Seleno-methionine accounted for 10% of total whole-blood Se in control animals, whereas the proportion in SY animals ranged between 40 and 75%. Glutathione peroxidase (EC 1.11.1.9) activity was greater (P < 0.05) in SY animals compared with controls. A range of other biochemical and hematological parameters were assessed, but few differences of biological significance were established between treatment groups. There were no differences between treatment groups within each species with regard to animal physical performance or overall animal health. It was concluded that there were no adverse effects on animal health, performance, and voluntary feed intake with the administration of at least 10 times the EU maximum, or approximately 20 times the US Food and Drug Administration permitted concentration of dietary Se in the form of SY derived from a specific strain of Saccharomyces cerevisiae CNCM I-3060.

Key Words: biochemistry • ruminant • selenium • selenomethionine tolerance

This article has been cited by other articles:

				S. G. Miranda, Y. J. Wang, N. G. Purdie, V. R. Osborne, B. L. Coomber, and J. P. Cant Selenomethionine stimulates expression of glutathione peroxidase 1 and 3 and growth of bovine mammary epithelial cells in primary culture J Dairy Sci, June 1, 2009; 92(6): 2670 - 2683. [Abstract] [Full Text] [PDF]

				D. B. Carlson, J. J. Reed, P. P. Borowicz, J. B. Taylor, L. P. Reynolds, T. L. Neville, D. A. Redmer, K. A. Vonnahme, and J. S. Caton Effects of dietary selenium supply and timing of nutrient restriction during gestation on maternal growth and body composition of pregnant adolescent ewes J Anim Sci, February 1, 2009; 87(2): 669 - 680. [Abstract] [Full Text] [PDF]