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Heart fatty acid binding protein is upregulated during porcine adipocyte development¹

Department of Animal Sciences, Ohio State University, Columbus, OH 43210

² Corresponding author: lee.2626{at}osu.edu

Heart fatty acid binding protein (H-FABP) has been associated with intramuscular fat content in pigs. In the current study, we showed that expression of H-FABP mRNA in adipose tissue of adult pigs was 8.5% of that in heart and 30% of that in skeletal muscle, and that H-FABP mRNA level was more than 10% of that of adipocyte fatty acid binding protein mRNA in adipose tissue. Levels of H-FABP mRNA reached a maximum in adipose tissue from 7-d neonates, with no further increase in the adult. Also, H-FABP mRNA was induced during adipogenic differentiation of stromal-vascular cells derived from adipose tissue and skeletal muscle. In conclusion, H-FABP may play a role in adipose tissue development and function in the pig.

Key Words: adipocyte fatty acid binding protein • adipose tissue • heart fatty acid binding protein • skeletal muscle

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