J. Anim Sci.
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J. Anim Sci. 1950. 9:484-490.
© 1950 American Society of Animal Science
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The B-Vitamins in Relation to a Cobalt Deficiency in Sheep1

W. H. Hale, A. L. Pope, P. H. Phillips and G. Bohstedt2, 3,

University of Wisconsin4

Abstract

Vitamin B12 injected into cobalt-deficient lambs in doses of 100 {gamma} daily (1 lamb) or given orally in 200 {gamma} daily doses (1 lamb) for a period of 4 weeks failed to produce a satisfactory response.

A complete B-vitamin supplement given daily by mouth for a period of 7 weeks reversed all symptoms of a cobalt deficiency (2 lambs). A supplement of only folic acid and pyridoxine aggravated a cobalt deficiency as measured by external appearances, hemoglobin values, weight losses, and a highly distorted lymphocyte and neutrophile ratio (2 lambs). A complete B-vitamin supplement less folic acid and pyridoxine in 2 other lambs gave varying results.

These data suggest that the physiological role of cobalt in sheep is by some route other than through vitamin By even though there is an extremely large synthesis of this vitamin in the rumen of cobalt-supplemented sheep. The beneficial action of cobalt may be through production of the members of the B-vitamins in the rumen.

Footnotes

1 Published with the approval of the Director of the Wisconsin Agricultural Experimenta Station. This work supported in part by the Wisconsin Alumni Research Foundation.

2 We are indebted to Merck and Co., Inc., Rahway, N. J., for crystalline vitamins and the vitamin B12 concentrate, and to Dr. B. L. Hutchings of the Lederle Laboratories Div., American Cyanamid Co., Pearl River, N. Y., for synthetic folic acid.

3 The crystalline vitamin B12 was generously supplied by Merck and Co., Inc., through the courtesy of Dr. D. F. Green.

4 Department of Animal Husbandry and Biochemistry, Madison, Wisconsin.






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