J. Anim Sci.
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J. Anim Sci. 1950. 9:387-403.
© 1950 American Society of Animal Science
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Physiological Effects of Thiouracil and Similar Drugs on Sheep1, 2,

E. R. Barrick, F. N. Andrews and W. M. Beeson3

Purdue University Agricultural Experiment Station

Abstract

The discovery of thiouracil and its derivatives as potent substances for inhibiting the function of the thyroid gland (Astwood, 1943; Astwood et al., I945 and McGinty and Bywater, I945) has made it possible to study some of the effects of limiting thyroid functions. A detailed report indicative of the effects of these substances on the thyroid gland is given by Astwood et al. (1943). They reported rapid enlargement of the thyroid glands of rats during the first few weeks of treatment. Microscopic examination showed a marked hyperplasia of the follicular epithelium, a decrease in stored colloid and an increase in vascularity of the glands. The thyroid glands of rats treated for two to six months with a diet containing 2 percent sulfagaanidine or 0.1 percent thiourea in the drinking water still exhibited an orderly cellular arrangement and upon cessation of treatment the glands rapidly regressed toward a normal condition.

Footnotes

1 Contribution from the Department of Animal Husbandry, Journal Paper No. 448, Purdue University Agricultural Experiment Station, Lafayette, Indiana.

2 A condensation of a portion of the thesis presented to the Graduate Faculty at Purdue University by the senior author in partial fulfillment of the requirements for the degree of Doctor of Philosophy, June, 1947.

3 The authors express their appreciation to Dr. K. K. Chen and Eli Lilly and Company for the thiouracil and propylthiouracil and to Dr. W. R. Graham and the Cerophyl Laboratories for the thyroprotein used.






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Copyright © 1950 by the American Society of Animal Science.