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Some Effects of Testosterone Propionate and Thyroprotein in Rams¹

University of Wisconsin

Abstract

Four groups of three rams each were studied on the following treatments during the interval from July to September, 1948: A. Control, B. Ten milligrams of testosterone propionate injected subcutaneously daily, C. One gram of thyroprotein per hundred pounds body weight daily, D. Ten milligrams of testosterone propionate plus one gram of thyroprotein per hundred pounds body weight daily. The control group demonstrated a slight loss in body weight and some decrease in sperm motility during the course of the experiment. There were also increases in sexual libido, total sperm, semen volume, and sperm concentration as the study progressed. The rams treated with testosterone, when compared with the controls, showed a significantly greater decrease in sperm concentration but changes in the other characters did not differ significantly. The group receiving thyroprotein showed a significantly greater loss in body weight and increase in reaction time than the controls. Semen volume, sperm concentration and motility, and total sperm were not significantly affected. Treatment with a combination of testosterone and thyroprotein resulted in a significantly greater weight loss than in the controls, but less than in the thyroprotein group. There was also a greater increase in semen volume, but changes in sperm concentration, motility, and total sperm did not differ significantly from the controls. There was some indication that testosterone may prevent the lowering of libido caused by thyroprotein.

¹ Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Paper from the Department of Genetics No. 412 and from the Department of Animal Husbandry.