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This Article Full Text Full Text (PDF) All Versions of this Article: jas.2008-1127v1 87/2/459    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Muñoz, G. Articles by Rodríguez, M. C. Search for Related Content PubMed PubMed Citation Articles by Muñoz, G. Articles by Rodríguez, M. C.

Single- and joint-population analyses of two experimental pig crosses to confirm quantitative trait loci on Sus scrofa chromosome 6 and leptin receptor effects on fatness and growth traits¹

G. Muñoz^*,2, C. Ovilo^*, L. Silió^*, A. Tomás, J. L. Noguera and M. C. Rodríguez^*

^* Departamento de Mejora Genética Animal, Subdirección General de Investigación y Tecnología-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, 28040 Madrid, Spain; and Departament de Ciència Animal i dels Aliments, Universidad Autónoma de Barcelona, 08193 Bellaterra, Spain; and Àrea de Genètica i Millora Animal, Centre Institut de Recerca i Tecnologia Agroalimentàries-Lleida, 25198 Lleida, Spain

² Corresponding author: munoz.gloria{at}inia.es

The primary goal of this study was to detect and confirm QTL on SSC6 for growth and fatness traits in 2 experimental F₂ intercrosses: Iberian x Landrace (IB x LR) and Iberian x Meishan (IB x MS), which were used in this study for the first time in a QTL analysis related to productive traits. For this purpose, single- and joint-population analyses with single and bivariate trait models of both populations were performed. The presence of the SSC6 QTL for backfat thickness previously identified in the IB x LR cross was detected in this population with additional molecular information, but also was confirmed in the IB x MS cross. In addition, a QTL affecting BW was detected in both crosses in a similar position to the QTL detected for backfat thickness. This is the first study in which a QTL affecting BW is detected on SSC6 in the IB x LR cross, as well as in the IB x MS resource population. Furthermore, we analyzed a previously described nonsynonymous leptin receptor (LEPR) SNP located in exon 14 (c.2002C > T) for causality with respect to this QTL within both F₂ populations. Our results supported the previously reported association between LEPR alleles and backfat thickness in the IB x LR cross, and this association was also confirmed within the IB x MS cross. An association not reported before between LEPR alleles and BW was identified in both populations.

Key Words: backfat thickness • body weight • joint analysis • leptin receptor • pig • polymorphism