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Prenatal stress effects on pig development and response to weaning¹

D. C. Lay, Jr^*,2, H. G. Kattesh, J. E. Cunnick, M. J. Daniels, K. A. McMunn^*, M. J. Toscano^*,3 and M. P. Roberts

^* ARS-USDA, Livestock Behavior Research Unit, West Lafayette, IN 47980; and Department of Animal Science, University of Tennessee, Knoxville 37996; and Department of Animal Science, Iowa State University, Ames 50014; and and Departments of Epidemiology & Biostatistics and Statistics, University of Florida, Gainesville 32611

² Corresponding author: Don.Lay{at}ars.usda.gov

Exposing a pregnant sow to stress has been shown to affect the resulting offspring. Our objective was to determine if rough handling of pregnant sows altered the physiology of her offspring and if these alterations were different from an experimentally induced model of prenatal stress. Sow treatments consisted of i.v. injections of ACTH (1 IU/kg of BW), exposure to rough handling for 10 min (Rough), or no treatment (Control) once a week during d 42 to 77 of gestation. To determine the plasma cortisol response to treatments, blood (5 mL) was collected from 30 sows after treatment administration. To conduct the prenatal stress study, a separate group of 56 sows was used in 1 of 4 replicates. At birth, production data were collected for each litter, including birth weight, number born, anogenital distance, and pig viability. At weaning, pigs were blocked by BW and sex, and placed in a nursery pen of 6 pigs, with 2 pigs from each treatment group. To assess the effect of treatments on cortisol, corticoste-roid-binding globulin (CBG), and hematological cell profiles, blood was collected every other day for 10 d after weaning. Application of treatments caused plasma cortisol concentrations to be greatest in ACTH sows compared with Control sows (P < 0.001), with Rough sows having intermediate values (P = 0.07). Treatments did not affect the number of pigs born, number of stillborn, or pig viability (P > 0.40). The ratio of cortisol to CBG did not differ between treatments (P = 0.09). Hematological variables did not differ between treatments (P > 0.19). Pigs born to ACTH sows had a smaller anogenital distance compared with controls (P < 0.03), with pigs from Rough sows being intermediate. Our data indicate that swine exposed to prenatal stress (ACTH injection) can have alterations in sexual morphology without effects on growth or the immune cell populations measured in this study.

Key Words: cortisol • corticosteroid-binding globulin • immune • prenatal • stress • swine