J. Anim Sci.
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J. Anim Sci. 2007. 85:1264-1273. doi:10.2527/jas.2006-751
© 2007 American Society of Animal Science

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Effects of Saccharomyces cerevisiae subspecies boulardii CNCM I-1079 on feed intake by healthy beef cattle treated with florfenicol and on health and performance of newly received beef heifers1

S. A. Keyser*, J. P. McMeniman*, D. R. Smith{ddagger}, J. C. MacDonald{dagger},{ddagger} and M. L. Galyean*,2

* Texas Tech University, Lubbock 79409; and {dagger} Texas A&M Research and Extension Center, Amarillo 79106; and and {ddagger} West Texas A&M University, Canyon 79016

2 Corresponding author: michael.galyean{at}ttu.edu

The effects of a live yeast supplement [Saccharomyces cerevisiae subspecies boulardii CNCM I-1079; ProTernative Stress Formula (PTSF) yeast, Ivy Natural Solutions, Overland Park, KS] on DMI, performance, and health of beef cattle were evaluated in 3 experiments. In Exp. 1, a pilot study was conducted with 10 healthy beef steers fed a 65% concentrate diet to evaluate the effects of florfenicol (s.c. in the neck vs. sterile water injection) on DMI. Steers injected with florfenicol had 15.6 (P = 0.092) and 22.2% (P = 0.015) decreases in DMI compared with controls on the day of and day after injection, respectively, with no differences for the remainder of the 7-d period. In the main study of Exp. 1, healthy beef steers (6 pens of 5 steers each/treatment) were fed the control or PTSF yeast diets (0.5 g of yeast·steer–1·d–1) for 5 d before being injected s.c. with florfenicol. Compared with the 5 d before injection, DMI decreased after injection, but it did not differ (P > 0.66) between treatments on the day of and day after injection. By the second day after injection, DMI tended (P = 0.107) to increase for steers fed PTSF yeast vs. control steers, with a trend for a similar pattern on the third day after injection (P = 0.197). No differences were noted between treatments for the remainder of the 7-d period or for the subsequent 2 wk. In Exp. 2, 3 loads of beef heifers (277 heifers; average initial BW = 230.3 kg) were shipped from auction barns and assigned randomly to 1 of 2 treatments (5 pens/treatment in each load) during 35-d receiving periods: 1) control = 65% concentrate receiving diet; or 2) PTSF yeast = 65% concentrate receiving diet with PTSF yeast added to supply 0.5 g of yeast·heifer–1·d–1. All heifers were treated with florfenicol on arrival, and PTSF yeast heifers received approximately 1 g of yeast via an oral paste at the time of processing. Averaged over the 3 loads, treatments did not affect (P ≥ 0.12) DMI, ADG, or G:F during the 35-d period, but the percentage of cattle treated once or more for bovine respiratory disease (BRD) was greater for control (P = 0.04) than for PTSF yeast heifers (24.0 vs. 13.78% respectively). In Exp. 3, 2 loads of beef heifers (180 heifers; average initial BW = 209.0 kg) that were not treated with antibiotic at the time of arrival processing were fed a 70% concentrate receiving diet and assigned the same 2 treatments as in Exp. 2. No differences (P > 0.72) were noted between treatments in ADG, DMI, and G:F for the 35-d receiving period, and BRD morbidity pooled across loads did not differ between treatments (40.2 vs. 33.1% for control vs. PTSF yeast). Providing PTSF yeast in an oral paste at the time of processing combined with the addition of 0.5 g of yeast·animal–1·d–1 in the diet had little effect on receiving period performance; however, it decreased BRD morbidity in heifers given florfenicol on arrival but was without effect on BRD morbidity in heifers that did not receive a prophylactic antibiotic.

Key Words: bovine respiratory disease • dry matter intake • feedlot beef cattle • florfenicol • Saccharomyces cerevisiae subspecies boulardii


1 Funded in part by grants from Lallemand Animal Nutrition, Milwaukee, WI 53218 and VetLife, West Des Moines, IA 50265. The Jessie W. Thornton Chair in Animal Science Endowment at Texas Tech Univ. and the Texas Agric. Exp. Sta. also provided funding to support this research. We thank Cactus Feeders Ltd. (Amarillo, TX) for providing cattle used in some experiments, and Cargill Corn Milling (Blair, NE), DSM Nutritional Products (Belvidere, NJ), Elanco Animal Health (Greenfield, IN), Fort Dodge Animal Health (Overland Park, KS), Intervet (Millsboro, DE), Kemin Industries (Des Moines, IA), and Schering-Plough Animal Health (Union, NJ) for supplying products used in the experiments. We also thank K. Robinson, R. Rocha, and L. Shaw for technical support.







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