HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: jas.2006-785v1 85/10/2721    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Reed, J. J. Articles by Caton, J. S. Search for Related Content PubMed PubMed Citation Articles by Reed, J. J. Articles by Caton, J. S.

Effects of selenium supply and dietary restriction on maternal and fetal body weight, visceral organ mass and cellularity estimates, and jejunal vascularity in pregnant ewe lambs¹

J. J. Reed^*,2, M. A. Ward^*,2,3, K. A. Vonnahme^*, T. L. Neville^*, S. L. Julius^*, P. P. Borowicz^*, J. B. Taylor, D. A. Redmer^*, A. T. Grazul-Bilska^*, L. P. Reynolds^* and J. S. Caton^*,4

^* Center for Nutrition and Pregnancy, Animal and Range Sciences Department, North Dakota State University, Fargo; and USDA-ARS, US Sheep Experiment Station, Dubois, ID

⁴ Corresponding author: joel.caton{at}ndsu.edu

To examine effects of nutrient restriction and dietary Se on maternal and fetal visceral tissues, 36 pregnant Targhee-cross ewe lambs were allotted randomly to 1 of 4 treatments in a 2 x 2 factorial arrangement. Treatments were plane of nutrition [control, 100% of requirements vs. restricted, 60% of controls] and dietary Se [adequate Se, ASe (6 µg/kg of BW) vs. high Se, HSe (80 µg/kg of BW)] from Se-enriched yeast. Selenium treatments were initiated 21 d before breeding and dietary restriction began on d 64 of gestation. Diets contained 16% CP and 2.12 Mcal/kg of ME (DM basis) and differing amounts were fed to control and restricted groups. On d 135 ± 5 (mean ± range) of gestation, ewes were slaughtered and visceral tissues were harvested. There was a nutrition x Se interaction (P = 0.02) for maternal jejunal RNA:DNA; no other interactions were detected for maternal measurements. Maternal BW, stomach complex, small intestine, large intestine, liver, and kidney mass were less (P 0.01) in restricted than control ewes. Lung mass (g/kg of empty BW) was greater (P = 0.09) in restricted than control ewes and for HSe compared with ASe ewes. Maternal jejunal protein content and protein:DNA were less (P 0.002) in restricted than control ewes. Maternal jejunal DNA and RNA concentrations and total proliferating jejunal cells were not affected (P 0.11) by treatment. Total jejunal and mucosal vascularity (mL) were less (P 0.01) in restricted than control ewes. Fetuses from restricted ewes had less BW (P = 0.06), empty carcass weight (P = 0.06), crown-rump length (P = 0.03), liver (P = 0.01), pancreas (P = 0.07), perirenal fat (P = 0.02), small intestine (P = 0.007), and spleen weights (P = 0.03) compared with controls. Fetuses from HSe ewes had heavier (P 0.09) BW, and empty carcass, heart, lung, spleen, total viscera, and large intestine weights compared with ASe ewes. Nutrient restriction resulted in less protein content (mg, P = 0.01) and protein:DNA (P = 0.06) in fetal jejunum. Fetal muscle DNA (nutrition by Se interaction, P = 0.04) concentration was greater (P < 0.05) in restricted ewes fed HSe compared with other treatments. Fetal muscle RNA concentration (P = 0.01) and heart RNA content (P = 0.04) were greater in HSe vs. ASe ewes. These data indicate that maternal dietary Se may alter fetal responses, as noted by greater fetal heart, lung, spleen, and BW.

Key Words: fetal • maternal • nutrient restriction • pregnancy • selenium

This article has been cited by other articles:

				T. J. Swanson, C. J. Hammer, J. S. Luther, D. B. Carlson, J. B. Taylor, D. A. Redmer, T. L. Neville, J. J. Reed, L. P. Reynolds, J. S. Caton, et al. Effects of gestational plane of nutrition and selenium supplementation on mammary development and colostrum quality in pregnant ewe lambs J Anim Sci, September 1, 2008; 86(9): 2415 - 2423. [Abstract] [Full Text] [PDF]

				M. A. Ward, T. L. Neville, J. J. Reed, J. B. Taylor, D. M. Hallford, S. A. Soto-Navarro, K. A. Vonnahme, D. A. Redmer, L. P. Reynolds, and J. S. Caton Effects of selenium supply and dietary restriction on maternal and fetal metabolic hormones in pregnant ewe lambs J Anim Sci, May 1, 2008; 86(5): 1254 - 1262. [Abstract] [Full Text] [PDF]

				T. L. Neville, M. A. Ward, J. J. Reed, S. A. Soto-Navarro, S. L. Julius, P. P. Borowicz, J. B. Taylor, D. A. Redmer, L. P. Reynolds, and J. S. Caton Effects of level and source of dietary selenium on maternal and fetal body weight, visceral organ mass, cellularity estimates, and jejunal vascularity in pregnant ewe lambs J Anim Sci, April 1, 2008; 86(4): 890 - 901. [Abstract] [Full Text] [PDF]