HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mercadé, A. Articles by Folch, J. M. Search for Related Content PubMed PubMed Citation Articles by Mercadé, A. Articles by Folch, J. M.

Adipocyte fatty-acid binding protein is closely associated to the porcine FAT1 locus on chromosome 4¹

A. Mercadé^*,2, M. Pérez-Enciso^,*, L. Varona, E. Alves, J. L. Noguera, A. Sánchez^* and J. M. Folch^*

^* Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain; and Institut Català de Recerca i Estudis Avançats, 08010, Barcelona, Spain; and Àrea de Producció Animal, Centre UdL-IRTA, 25198, Lleida, Spain; and Departamento de Mejora Genética Animal SGIT-INIA, 28040, Madrid, Spain

² Corresponding author: Anna.mercader{at}uab.es

We identified 22 polymorphisms in the adipocyte fatty-acid binding protein (FABP4) gene, a strong positional candidate gene for the FAT1 locus in porcine chromosome 4. The most informative polymorphism, an insertion/deletion in intron 1, together with a single nucleotide polymorphism in intron 3, was genotyped in a cross between Iberian and Landrace pigs. After performing QTL, single marker, and haplotype analyses, we showed that there were at least 2 quantitative trait genes in the FAT1 region and that the FABP4 polymorphism was tightly associated to fatness. A comparison of allelic frequencies in a panel of pig breeds suggested that the Del2634C polymorphism was under indirect selection. We also showed that FABP4 is tightly associated to fatness but not growth. Furthermore, a haplotype analysis suggests that there is genetic heterogeneity at the FAT1 locus within the Landrace breed.

Key Words: FABP4 • FAT1 • fatness • pig • QTL

This article has been cited by other articles:

				A. Ojeda, J. Rozas, J. M. Folch, and M. Perez-Enciso Unexpected High Polymorphism at the FABP4 Gene Unveils a Complex History for Pig Populations Genetics, December 1, 2006; 174(4): 2119 - 2127. [Abstract] [Full Text] [PDF]