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Factors associated with ELISA scores for paratuberculosis in an Angus-Brahman multibreed herd of beef cattle¹

M. A. Elzo^*,2, D. O. Rae, S. E. Lanhart, J. G. Wasdin^*, W. P. Dixon^* and J. L. Jones^*

^* Department of Animal Sciences, University of Florida, Gainesville 32611-0910; and and Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136

² Corresponding author: elzo{at}animal.ufl.edu

Cow and calf genetic and environmental factors were evaluated for their association with ELISA scores for paratuberculosis in a multibreed population of beef cattle. The ELISA scores are a measure of the presence or absence of antibodies against Mycobacterium avium subsp. paratuberculosis in bovine serum. The linear mixed-model analysis used 352 ELISA scores from 238 cows: 51 Angus (A); 34 Brahman (B); 41 ( A B); 45 ( A B); 34 ( A B); and 33 Brangus ( A B). Cows were assumed to be unrelated. Year affected (P < 0.001) ELISA scores, but age of cow did not, which was expected to be significant because of the chronic progressive nature of this disease. Important regressions on fixed effects associated with cows were 1) a positive estimate of cow B breed effect (0.59 ± 0.24; P < 0.017), indicating an upward trend of ELISA scores toward 100% B cows; 2) a negative estimate for weight change from before calving (late November) to the date of the blood sample in May (–0.0062 ± 0.0019 score/kg; P < 0.002), indicating that poorer maintenance of cow weights was associated with higher ELISA scores; and 3) a positive estimate for days in lactation of cow on the date of the blood sample (0.0086 ± 0.0034 score/d; P < 0.021), indicating the production of larger amounts of antibodies against Mycobacterium avium subsp. paratuberculosis as lactation progressed. Relevant regressions on fixed effects associated with calves were 1) calf birth weight (–0.022 ± 0.010 score/kg; P < 0.035), and 2) calf gain from birth to the date of the cow blood sample (–0.0092 ± 0.0027 score/kg; P < 0.001). These estimates indicate that cows that produced lighter calves at birth and/or calves with slower preweaning growth tended to have greater ELISA scores. Although the sensitivity (percentage of infected animals detected) of ELISA was only 50%, these results suggest that subclinical paratuberculosis may be negatively affecting cows and their offspring. Factors identified as associated with ELISA scores could help producers with culling decisions related to paratuberculosis control and eradication in beef cattle.

Key Words: beef • cattle • Johne’s disease • multibreed • Mycobacterium avium subspecies paratuberculosis • paratuberculosis