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Associations of polymorphisms in the Pit-1 gene with growth and carcass traits in Angus beef cattle^1,2

Department of Animal Sciences, The Ohio State University, Columbus 43210

³ Correspondence: Children’s Research Institute, Columbus Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205 (phone: 614-722-3070; fax: 614-722-2774; e-mail: zhao.62{at}osu.edu).

The Pit-1 gene was studied as a candidate for genetic markers of growth and carcass traits. Angus beef cattle that were divergently selected for high– or low–blood serum IGF-I concentration were used in this study. The single-strand conformation polymorphism method was used to identify polymorphism in the Pit-1 gene including regions from intron 2 to exon 6. Two polymorphisms, Pit1I3H (HinfI) and Pit1I3NL (NlaIII), were detected in intron 3 of the Pit-1 gene. One polymorphism, Pit1I4N (BstNI), was found in intron 4, and a single nucleotide polymorphism, Pit1I5, was found in intron 5. The previously reported polymorphism in exon 6, Pit1E6H (HinfI), was also studied in 416 Angus beef cattle. Associations of the polymorphisms with growth traits, carcass traits, and IGF-I concentration were analyzed using a general linear model procedure. No significant associations were observed between these polymorphisms and growth and carcass traits.

Key Words: Beef Cattle • Carcass Traits • Growth Traits • Pit-1 • Polymorphism