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Changes in plasma ghrelin and growth hormone concentrations in mature Holstein cows and three-month-old calves¹

H. Miura^*,2, N. Tsuchiya^*, I. Sasaki^*, M. Kikuchi^*, M. Kojima, K. Kangawa, Y. Hasegawa and Y. Ohnami^*

^* Laboratory of Veterinary Theriogenology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada-shi, Aomori 034-8628, Japan; and National Cardiovascular Center Research Institute, Osaka 565-8565, Japan; and and Laboratory of Experimental Animal Science, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada-shi, Aomori 034-8628, Japan

² Correspondence—fax: +81 176-23-8703; e-mail: miurah{at}vmas.kitasato-u.ac.jp.

Abstract

We measured changes in plasma ghrelin and GH concentrations in mature Holstein cows and 3-mo-old female Holstein calves fed at scheduled times. Our objective was to determine the characteristics of ghrelin secretion in dairy cattle and its influence on GH. Animals were fed at 0800 and 1600 for 2 wk before and during experiments. Plasma was sampled for 24 h at 2-h intervals in Exp. 1. In mature cows, plasma ghrelin concentrations decreased (P < 0.01) just after 0800 but not at the 1600 feeding. Ghrelin concentrations were lower (P < 0.01) in calves than in mature cows and they did not decrease after feeding in calves. The temporal relationship between ghrelin and GH remained unclear. In Exp. 2, plasma was sampled 2 h before and after both morning and evening feedings at 20-min intervals. Plasma ghrelin concentrations decreased (P < 0.05) 40 min after 0800 feeding and 60 min after 1600 feeding in mature cows. These results indicate that in mature cows, plasma ghrelin concentration decreased after feeding, but this decrease was not evident in 3-mo-old calves. Further studies are required to define the relationship between plasma ghrelin and GH concentrations.

Key Words: Calves • Cows • Feeding • Ghrelin • Growth Hormone

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