HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Burkey, T. E. Articles by Minton, J. E. Search for Related Content PubMed PubMed Citation Articles by Burkey, T. E. Articles by Minton, J. E.

Effect of dietary mannanoligosaccharide and sodium chlorate on the growth performance, acute-phase response, and bacterial shedding of weaned pigs challenged with Salmonella entericaserotype Typhimurium¹

T. E. Burkey^*, S. S. Dritz, J. C. Nietfeld, B. J. Johnson^* and J. E. Minton^*,2

¹ Departments of Animal Sciences and Industry and and Diagnostic Medicine/Pathobiology Kansas State University, Manhattan 66506

² Correspondence: 253 Weber Hall (phone: 785-532-1238; fax: 785-532-7059. e-mail: eminton{at}ksu.edu).

Abstract

A 28-d experiment evaluated the growth, acute-phase response, and bacterial shedding patterns in pigs (n = 96; initially 6.8 ± 1.3 kg) fed mannanoligosaccharides (MANNAN) and sodium chlorate (CHLORATE) before and after oral challenge with Salmonella enterica serotype Typhimurium (ST). The negative control diet contained no antimicrobial (CON), and the positive control contained carbadox (CARB; 55 ppm). Test diets contained (as-fed basis) MANNAN (1,500 ppm) or CHLORATE (800 ppm). Pigs were fed diets for 14 d and then given ST orally. Pigs fed CARB had greater ADG over the entire study than pigs from other treatments (P < 0.05). During wk 1 to 2, before ST challenge, feed intake (as-fed basis) was lower for pigs fed MANNAN and CHLORATE than pigs fed CARB (P < 0.05). During the final 2 wk, pigs fed CARB had greater feed intake than pigs on other treatments (P < 0.05). Gain/feed was greater for pigs fed CARB in the 2 wk before ST (P < 0.05); however, in wk 3 to 4 after ST, gain/feed was reduced for CON pigs compared to pigs on other treatments (P < 0.05). Serum IGF-I was decreased at 2 and 4 d after ST (P < 0.001), and, overall, IGF-I was greater in pigs fed CARB than CON or CHLORATE (P < 0.05). Serum haptoglobin concentrations were greater (P < 0.001) for all treatments at d 6 compared with d 13 after ST. Overall, haptoglobin was greater for MANNAN than for CARB and CHLORATE (P < 0.05) and tended to be increased (P < 0.06) relative to CON. Interleukin-6 was not affected by treatment or day post-ST challenge. Fecal shedding of salmonellae organisms was less for CHLORATE (P < 0.05) than all other treatments at 7 d after ST. Shedding scores decreased from d 7 to 14 after ST (P < 0.05) for the CON, CARB, and MANNAN treatments. We conclude that feeding MANNAN and CHLORATE before acute enteric disease challenge may support improved gut function as evidenced by improved gain/feed, and that CHLORATE may decrease bacterial shedding. But neither MANNAN nor CHLORATE enhanced growth relative to the absence of dietary antimicrobials, nor was either treatment as effective as CARB following ST challenge.

Key Words: Antimicrobial • Mannans • Pigs • Salmonella • Sodium chlorate

This article has been cited by other articles:

				S. R. Hill, B. A. Hopkins, S. Davidson, S. M. Bolt, D. E. Diaz, C. Brownie, T. Brown, G. B. Huntington, and L. W. Whitlow The addition of cottonseed hulls to the starter and supplementation of live yeast or mannanoligosaccharide in the milk for young calves J Dairy Sci, February 1, 2009; 92(2): 790 - 798. [Abstract] [Full Text] [PDF]

				J. A. Carroll Bidirectional communication: Growth and immunity in domestic livestock J Anim Sci, April 1, 2008; 86(14_suppl): E126 - E137. [Abstract] [Full Text] [PDF]

				J. N. Fraser, B. L. Davis, K. A. Skjolaas, T. E. Burkey, S. S. Dritz, B. J. Johnson, and J. E. Minton Effects of feeding Salmonella enterica serovar Typhimurium or serovar Choleraesuis on growth performance and circulating insulin-like growth factor-I, tumor necrosis factor-{alpha}, and interleukin-1{beta} in weaned pigs J Anim Sci, May 1, 2007; 85(5): 1161 - 1167. [Abstract] [Full Text] [PDF]

				B. J. Johnson, S. S. Dritz, K. A. Skjolaas-Wilson, T. E. Burkey, and J. E. Minton Interactive responses in gut immunity, and systemic and local changes in the insulin-like growth factor system in nursery pigs in response to Salmonella enterica serovar Typhimurium J Anim Sci, June 1, 2005; 83(13_suppl): E48 - 56. [Abstract] [Full Text] [PDF]

				G. F. Yi, J. A. Carroll, G. L. Allee, A. M. Gaines, D. C. Kendall, J. L. Usry, Y. Toride, and S. Izuru Effect of glutamine and spray-dried plasma on growth performance, small intestinal morphology, and immune responses of Escherichia coli K88+-challenged weaned pigs J Anim Sci, March 1, 2005; 83(3): 634 - 643. [Abstract] [Full Text] [PDF]