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Abundance of message for insulin-like growth factors-I and -II and for receptors for growth hormone, insulin-like growth factors-I and -II, and insulin in the intestine and liver of pre- and full-term calves¹

T. M. Georgieva^*,2, I. P. Georgiev^*,2, E. Ontsouka^*, H. M. Hammon^*, M. W. Pfaffl and J. W. Blum^*,3

^* Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing, Faculty of Veterinary Medicine, University of Berne, CH-3012 Berne, Switzerland and and Institute of Physiology, FML-Weihenstephan, Center of Life and Food Sciences, Technical University of Munich, D-85354 Freising-Weihenstephan, Germany

³ Correspondence: Bremgartenstr. 109a (phone: +41-31-6312324; fax: +41-31-6312640; E-mail: juerg.blum{at}itz.unibe.ch).

The somatotropic axis and insulin are involved in pre- and postnatal development. In pre- and full-term calves (GrP_o and GrN_o; born after 277 and 290 d of pregnancy, respectively) and in preterm calves on d 8 of life after being fed for 7 d (GrP₈), we studied whether there are differences in the abundance of messenger RNA (mRNA) of IGF-I and IGF-II and of receptors for GH, IGF-I, IGF-II, and insulin among different intestinal sites (duodenum, jejunum, ileum, and colon) and whether there are ontogenetic differences during the perinatal period in intestine and liver. Intestinal site differences (P < 0.05) existed in mRNA levels of IGF-I and IGF-II and receptors for GH, IGF-I, IGF-II, and insulin. Abundance of mRNA of IGF-I and -II and of receptors for IGF-I and GH was highest (P < 0.05) in the colon, abundance of the receptor for IGF-II was comparably high in the colon and ileum, and that of the receptor for insulin was similarly high in colon, ileum, and jejunum. Among GrP_o, GrN_o, and GrP₈ groups, there were differences (P < 0.05) in mRNA levels of IGF-I and IGF-II and of receptors for GH, IGF-I, IGF-II and insulin. Abundance of mRNA of IGF-I and IGF-II and of receptors for GH, IGF-I, IGF-II and insulin was highest (P < 0.05) in GrP_o calves immediately after birth and was primarily seen in the ileum. In liver, the mRNA levels differed (P < 0.05) among groups for IGF-II and receptors for IGF-I, IGF-II, and insulin, and were highest (P < 0.05) for IGF-II in GrP_o, for receptors of IGF-I in GrN_o, and were higher (P < 0.05) in GrP_o than GrP₈ for receptors of IGF-II. In conclusion, mRNA levels of IGF-I and IGF-II and of receptors for GH, IGF-I, IGF-II, and insulin were different at different intestinal sites and in intestine and liver and changed during the perinatal period.

Key Words: Calves • Insulin-Like Growth Factor • Intestine • Liver • Messenger Ribonucleic Acid • Somatotropin

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