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* Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada;
and
Lacombe Research Centre, AAFRD, Lacombe, Alberta T4L 1W1, Canada;
and
USDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE 68933-0166; and
and
Agriculture and Agri-Food Canada, Lethbridge Research Center, Alberta TIJ 4B1, Canada
2 Correspondence: 4-10 Ag/For Building, (phone: 780-492-0169; fax: 780-492-4265; E-mail: stephen.moore{at}ualberta.ca).
Backfat thickness is one of the major quantitative traits that affect carcass quality in beef cattle. In this study, we have fine mapped a QTL for backfat EBV on bovine chromosome 14, using an identical-by-descent haplotype-sharing analysis, in a commercial line of Bos taurus. We also examined the association between gene-specific single nucleotide polymorphism (SNP) markers of the genes diacylgcerol acyltransferase 1 (DGAT1) and thyroglobulin (TG) and the backfat EBV. The results indicate that the QTL region for backfat identified on chromosome 14 is in agreement with previous studies. However, neither of the two polymorphisms of candidate genes tested, DGAT1 nor TG, showed a significant (P > 0.10) association with the backfat EBV in the cattle populations examined. However, a strong association (P = 0.0058) was detected between a microsatellite marker (CSSM66) lying approximately mid-way between the two candidate genes and the backfat EBV. These results suggest that other SNP of DGAT1, TG, or other gene(s) in the chromosomal region should be examined to test whether they have a significant effect on lipid metabolism.
Key Words: Backfat • Cattle • Marker Genes • Quantitative Trait Loci
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