| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Kansas State University, Manhattan 66506
6 Correspondence:
253 Weber Hall (phone: 785-532-1238; fax: 785-532-7059; E-mail:
eminton{at}oznet.ksu.edu).
Ninety-five pigs (initially 7.1 kg and 24 d of age) were used in a 28-d experiment to determine the effects of Ascophyllum nodosum seaweed extract (ANOD) on young pig growth performance and immune function in response to enteric disease challenge with Salmonella typhimurium (ST). Experimental treatments were arranged in a 2 x 4 factorial with main effects of disease challenge (control vs ST-challenge) and dietary addition of ANOD (0, 0.5, 1.0, and 2.0% of diet). Pigs were fed ANOD diets for 14 d and then challenged orally with ST or sterile media. There were no main effects of ANOD on growth performance end points, although there were significant quadratic effects of ANOD on ADG (P < 0.04) and final weight (P < 0.003), both being greatest at 1.0% ANOD. There was a positive linear effect of ANOD inclusion on ADFI (P < 0.07) and a negative linear effect on the gain-to-feed ratio (G/F) (P < 0.05). ST-challenge reduced ADG (P < 0.05), ADFI (P < 0.05), and G/F (P < 0.05) in the first week following challenge. Daily estimates revealed reductions in feed intake in ST-infected pigs on d 2 to 4 following infection (P < 0.05). Rectal temperature was increased maximally 2 d following ST-infection (P < 0.05). A disease challenge x time interaction (P < 0.001) was observed for serum haptoglobin and 
1-acid glycoprotein. Serum immunoglobulin M (IgM) was not influenced by disease challenge, but IgM declined (P < 0.001) in all pigs over time. Serum immunoglobulin G (IgG) also was not influenced by disease challenge, but IgG tended (P < 0.08) to increase over time. In vitro culture of porcine alveolar macrophages with 10 mg/mL ANOD elevated (P < 0.05) prostaglandin E2 (PGE2) production over that of controls at 3 and 24 h of culture. There was no interleukin-10 response by porcine splenocytes cultured in vitro with 0.005, 0.05, 0.5, or 5 mg/mL ANOD. We conclude that this model of enteric disease elicits an acute phase response that is accompanied by increased rectal temperature and diminished feed intake. Furthermore, our results indicate some beneficial effects of dietary ANOD on growth performance and no influence of dietary ANOD on immune response in the presence or absence of ST-challenge. However, high ANOD concentrations are capable of activating porcine alveolar macrophages in vitro to secrete PGE2.
Key Words: Disease Resistance • Pigs • Salmonella • Seaweeds
This article has been cited by other articles:
|
|
 |
|
  T. Shan, Y. Wang, Y. Wang, J. Liu, and Z. Xu Effect of dietary lactoferrin on the immune functions and serum iron level of weanling piglets J Anim Sci, September 1, 2007; 85(9): 2140 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Fraser, B. L. Davis, K. A. Skjolaas, T. E. Burkey, S. S. Dritz, B. J. Johnson, and J. E. Minton Effects of feeding Salmonella enterica serovar Typhimurium or serovar Choleraesuis on growth performance and circulating insulin-like growth factor-I, tumor necrosis factor-{alpha}, and interleukin-1{beta} in weaned pigs J Anim Sci, May 1, 2007; 85(5): 1161 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Salak-Johnson and J. J. McGlone Making sense of apparently conflicting data: Stress and immunity in swine and cattle J Anim Sci, March 1, 2007; 85(13_suppl): E81 - E88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Archer, T. H. Friend, D. Caldwell, K. Ameiss, and P. D. Krawczel Effect of the seaweed Ascophyllum nodosum on lambs during forced walking and transport J Anim Sci, January 1, 2007; 85(1): 225 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. B. Sandberg, G. C. Emmans, and I. Kyriazakis A model for predicting feed intake of growing animals during exposure to pathogens J Anim Sci, June 1, 2006; 84(6): 1552 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Johnson, S. S. Dritz, K. A. Skjolaas-Wilson, T. E. Burkey, and J. E. Minton Interactive responses in gut immunity, and systemic and local changes in the insulin-like growth factor system in nursery pigs in response to Salmonella enterica serovar Typhimurium J Anim Sci, June 1, 2005; 83(13_suppl): E48 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Burkey, S. S. Dritz, J. C. Nietfeld, B. J. Johnson, and J. E. Minton Effect of dietary mannanoligosaccharide and sodium chlorate on the growth performance, acute-phase response, and bacterial shedding of weaned pigs challenged with Salmonella entericaserotype Typhimurium J Anim Sci, February 1, 2004; 82(2): 397 - 404. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
