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Journal of Animal Science, Vol 80, Issue 3 702-707, Copyright © 2002 by American Society of Animal Science

EVALUATION STUDIES

Relative bioactivity of dietary RRR- and all-rac-alpha-tocopheryl acetates in swine assessed with deuterium-labeled vitamin E

C. Lauridsen, H. Engel, A. M. Craig and M. G. Traber
Department of Animal Nutrition and Physiology, Research Centre Foulum, Tjele, Denmark. charlotte.lauridsen@agrsci.dk

This study evaluated the relative bioactivities of natural and synthetic stereoisomers of alpha-tocopherol in swine. Deuterium-labeled vitamin E (150 mg each of d3-RRR- [natural] and d6-all-rac- [synthetic] alpha-tocopheryl acetates) was administered orally to adult female pigs (n = 3) with the morning feed. Blood samples were obtained at 0, 3, 6, 9, 12, 36, 48, and 72 h after the dose. The time of maximum plasma d3-alpha-tocopherol concentration (0.486 microg/mL) occurred at 12 h, and d6-alpha-tocopherol peaked earlier (at 9 h) and at a lower (P < 0.05) concentration (0.288 microg/mL). The d3-/d6-alpha-tocopherol ratio increased from 1.35 (SD = 0.73) at 3 h after dosing to 2.0 (SD = 0.14) at 72 h (P = 0.03). The plasma disappearance rates of d3- and d6-alpha-tocopherols (post-maximum concentrations) were similar and were estimated to be 0.013 microg/mL per hour. In summary, swine discriminated between RRR- and all-rac-alpha-tocopherols, which resulted in an approximately twofold higher plasma alpha-tocopherol concentration arising from the RRR-form. This 2:1 ratio of RRR- to all-rac- is higher than the currently accepted USP definition of RRR-:all-rac- of 1.36:1.00.


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H. Yang, D. C. Mahan, D. A. Hill, T. E. Shipp, T. R. Radke, and M. J. Cecava
Effect of vitamin E source, natural versus synthetic, and quantity on serum and tissue {alpha}-tocopherol concentrations in finishing swine
J Anim Sci, December 1, 2009; 87(12): 4057 - 4063.
[Abstract] [Full Text] [PDF]

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 J. Nutr.Home page
C. Lauridsen, H. Engel, S. K. Jensen, A. M. Craig, and M. G. Traber
Lactating Sows and Suckling Piglets Preferentially Incorporate RRR- over All-rac-{alpha}-Tocopherol into Milk, Plasma and Tissues
J. Nutr., June 1, 2002; 132(6): 1258 - 1264.
[Abstract] [Full Text] [PDF]


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Copyright © 2002 by the American Society of Animal Science.