| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Animal Science, Vol 79, Issue 3 616-622, Copyright © 2001 by American Society of Animal Science
JOURNAL ARTICLE |
D. J. de Koning, N. F. Schulmant, K. Elo, S. Moisio, R. Kinos, J. Vilkki and A. Maki-Tanila
Animal Breeding and Genetics Group, WIAS, Wageningen University, The Netherlands.
Detection of QTL in outbred half-sib family structures has mainly been based on interval mapping of single QTL on individual chromosomes. Methods to account for linked and unlinked QTL have been developed, but most of them are only applicable in designs with inbred species or pose great demands on computing facilities. This study describes a strategy that allows for rapid analysis, involving multiple QTL, of complete genomes. The methods combine information from individual analyses after which trait scores for a specific linkage group are adjusted for identified QTL at other linkage groups. Regression methods are used to estimate QTL positions and effects; permutation tests are used to obtain empirical threshold values. The description of the methods is complemented by an example of the combined analysis of 28 bovine chromosomes and their associations with milk yield in Finnish Ayrshire cattle. In this example, the individual analysis revealed five suggestive QTL affecting milk yield. Following the strategy presented in this paper, the final combined analysis showed eight significant QTL affecting milk yield. This clearly demonstrates the potential gain of using the combined analysis. The use of regression methods, with low demands on computing resources, makes this approach very practical for total genome scans.
This article has been cited by other articles:
|
|
 |
|
  W. M. Stoop, A. Schennink, M. H. P. W. Visker, E. Mullaart, J. A. M. van Arendonk, and H. Bovenhuis Genome-wide scan for bovine milk-fat composition. I. Quantitative trait loci for short- and medium-chain fatty acids J Dairy Sci, September 1, 2009; 92(9): 4664 - 4675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Daetwyler, F. S. Schenkel, M. Sargolzaei, and J. A. B. Robinson A Genome Scan to Detect Quantitative Trait Loci for Economically Important Traits in Holstein Cattle Using Two Methods and a Dense Single Nucleotide Polymorphism Map J Dairy Sci, August 1, 2008; 91(8): 3225 - 3236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bagnato, F. Schiavini, A. Rossoni, C. Maltecca, M. Dolezal, I. Medugorac, J. Solkner, V. Russo, L. Fontanesi, A. Friedmann, et al. Quantitative Trait Loci Affecting Milk Yield and Protein Percentage in a Three-Country Brown Swiss Population J Dairy Sci, February 1, 2008; 91(2): 767 - 783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chamberlain, H. C. McPartlan, and M. E. Goddard The Number of Loci That Affect Milk Production Traits in Dairy Cattle Genetics, October 1, 2007; 177(2): 1117 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Holmberg and L. Andersson-Eklund Quantitative trait Loci affecting fertility and calving traits in Swedish dairy cattle. J Dairy Sci, September 1, 2006; 89(9): 3664 - 3671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Khatib, S. D. Leonard, V. Schutzkus, W. Luo, and Y. M. Chang Association of the OLR1 Gene with Milk Composition in Holstein Dairy Cattle J Dairy Sci, May 1, 2006; 89(5): 1753 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Heifetz, J. E. Fulton, N. O'Sullivan, H. Zhao, J. C. M. Dekkers, and M. Soller Extent and Consistency Across Generations of Linkage Disequilibrium in Commercial Layer Chicken Breeding Populations Genetics, November 1, 2005; 171(3): 1173 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Szyda, Z. Liu, F. Reinhardt, and R. Reents Estimation of Quantitative Trait Loci Parameters for Milk Production Traits in German Holstein Dairy Cattle Population J Dairy Sci, January 1, 2005; 88(1): 356 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bennewitz, N. Reinsch, V. Guiard, S. Fritz, H. Thomsen, C. Looft, C. Kuhn, M. Schwerin, C. Weimann, G. Erhardt, et al. Multiple Quantitative Trait Loci Mapping With Cofactors and Application of Alternative Variants of the False Discovery Rate in an Enlarged Granddaughter Design Genetics, October 1, 2004; 168(2): 1019 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Holmberg and L. Andersson-Eklund Quantitative Trait Loci Affecting Health Traits in Swedish Dairy Cattle J Dairy Sci, August 1, 2004; 87(8): 2653 - 2659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhang, D.-J. de Koning, J. Hernandez-Sanchez, C. S. Haley, J. L. Williams, and P. Wiener Mapping of Multiple Quantitative Trait Loci Affecting Bovine Spongiform Encephalopathy Genetics, August 1, 2004; 167(4): 1863 - 1872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. F. Schulman, S. M. Viitala, D. J. de Koning, J. Virta, A. Maki-Tanila, and J. H. Vilkki Quantitative Trait Loci for Health Traits in Finnish Ayrshire Cattle J Dairy Sci, February 1, 2004; 87(2): 443 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Viitala, N. F. Schulman, D. J. de Koning, K. Elo, R. Kinos, A. Virta, J. Virta, A. Maki-Tanila, and J. H. Vilkki Quantitative Trait Loci Affecting Milk Production Traits in Finnish Ayrshire Dairy Cattle J Dairy Sci, May 1, 2003; 86(5): 1828 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Olsen, L. Gomez-Raya, D. I. Vage, I. Olsaker, H. Klungland, M. Svendsen, T. Adnoy, A. Sabry, G. Klemetsdal, N. Schulman, et al. A Genome Scan for Quantitative Trait Loci Affecting Milk Production in Norwegian Dairy Cattle J Dairy Sci, November 1, 2002; 85(11): 3124 - 3130. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
