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Journal of Animal Science, Vol 77, Issue 5 1249-1257, Copyright © 1999 by American Society of Animal Science

JOURNAL ARTICLE

The brain-pituitary-adipocyte axis: role of leptin in modulating neuroendocrine function

C. R. Barb
USDA, ARS, Richard B. Russell Agriculture Research Center, Athens, GA 30604-5677, USA. rbarb@ars.usda.gov

The recently discovered protein leptin has a molecular mass of 16 kDa, consists of 146 amino acids, and is synthesized and secreted by adipose tissue. Leptin affects feed intake, the neuroendocrine-axis, and immunological processes. The protein was first identified as the gene product that is deficient in the obese ob/ob mouse. Leptin serves as a circulating signal of nutritional status and plays a pivotal role in regulation of body weight, energy expenditure, growth, and reproduction.


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Copyright © 1999 by the American Society of Animal Science.