J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wester, T. J.
Right arrow Articles by Burrin, D. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wester, T. J.
Right arrow Articles by Burrin, D. G.

Journal of Animal Science, Vol 76, Issue 12 3003-3009, Copyright © 1998 by American Society of Animal Science

JOURNAL ARTICLE

Feeding colostrum increases circulating insulin-like growth factor I in newborn pigs independent of endogenous growth hormone secretion

T. J. Wester, M. L. Fiorotto, J. Klindt and D. G. Burrin
Children's Nutrition Research Center, ARS, USDA, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

Our objective was to examine the influence of feeding and endogenous GH secretion on circulating IGF-I in colostrum-deprived newborn pigs fed colostrum (n = 4), formula (control, n = 4), or water (n = 4). In another four formula-fed pigs, GH was ablated (GRF-A) with two intravenous injections of a GH releasing-factor antagonist (N-Ac-Tyr1,D-Arg2)-GRF(1-29)-NH2. Blood was serially sampled in all pigs to measure plasma IGF-I and GH profiles. Feeding increased plasma IGF-I concentration two- to fourfold and decreased GH secretion. Despite a more than 80% decrease in the plasma GH in GRF-A pigs, the circulating IGF-I concentration was similar to that in control pigs. In colostrum-fed pigs, plasma IGF-I was higher than that in control pigs, despite equal nutrient intake and lower circulating GH. There were no differences in plasma IGF binding protein (IGFBP)-3 levels among the treatment groups. However, the relative abundance of plasma IGFBP-4 was lower, and that of IGFBP-1 higher, in unfed pigs than in any of the three fed groups. The plasma insulin concentration was not different among fed pigs, but it was lower in unfed pigs. Our results indicate that the circulating IGF-I concentration is more dependent on nutrient intake than on GH in newborn pigs, despite relatively high GH concentrations. However, because the nutrient content in the formula was designed to match that of colostrum, a factor other than nutrient intake and GH was responsible for the maximal increase in circulating IGF-I concentration observed in colostrum-fed pigs.


This article has been cited by other articles:


Home page
 JPEN J Parenter Enteral NutrHome page
P. M. Pereira-Fantini, S. L. Thomas, R. G. Taylor, E. Nagy, M. Sourial, P. J. Fuller, and J. E. Bines
Colostrum Supplementation Restores Insulin-like Growth Factor -1 Levels and Alters Muscle Morphology Following Massive Small Bowel Resection
JPEN J Parenter Enteral Nutr, May 1, 2008; 32(3): 266 - 275.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. S. Khan, M. L. Fiorotto, K. K. Cummings, M. A. Pope, P. A. Brown, and R. Draghia-Akli
Maternal GHRH plasmid administration changes pituitary cell lineage and improves progeny growth of pigs
Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E224 - E231.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
V. Gerfault, I. Louveau, J. Mourot, and J. Le Dividich
Proliferation and Differentiation of Stromal-Vascular Cells in Primary Culture Differ between Neonatal Pigs Consuming Maternal or Formula Milk
J. Nutr., May 1, 2000; 130(5): 1179 - 1182.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society of Animal Science.