Journal of Animal Science, Vol 74, Issue 7 1541-1547, Copyright © 1996 by American Society of Animal Science

JOURNAL ARTICLE

Serum insulin-like growth factor I (IGF-I) concentrations are increased in pigs fed antimicrobials

M. R. Hathaway, W. R. Dayton, M. E. White, T. L. Henderson and T. B. Henningson
Department of Animal Science, University of Minnesota, St. Paul 55108, USA.

The effect of antimicrobial supplementation on the sera concentrations of IGF-I was determined in crossbred weanling pigs. Pigs were allotted by weight, litter, and sex to either a control diet or a diet supplemented with ASP-250 (22.7 ppm of chlortetracycline, 22.7 ppm of sulfamethazine, and 11.4 ppm of penicillin) for 5 wk. The diets contained 21.8% crude protein and 1.15% lysine. Growth performance data were collected weekly. Insulin-like growth factor I and insulin-like growth factor binding protein (IGFBP) analyses were performed on blood samples that were drawn during the final week of the trial. Feeding ASP-250 to young pigs increased their sera IGF-I concentrations by 24.8% (P < .001). A 59% increase in sera IGFBP-3 levels also was observed. The pigs fed ASP-250 had a 26% increase in average daily gain (P < .01), a 6.7% improvement in gain:feed ratio (P < .05), and a 18.5% increase in feed consumption (P < .01) compared with pigs fed the control diet. Increased serum IGF-I concentrations with antimicrobial feeding may be involved in the enhanced growth performance observed.

This article has been cited by other articles:

				Z. Jin, Y. X. Yang, J. Y. Choi, P. L. Shinde, S. Y. Yoon, T.-W. Hahn, H. T. Lim, Y. Park, K.-S. Hahm, J. W. Joo, et al. Potato (Solanum tuberosum L. cv. Gogu valley) protein as a novel antimicrobial agent in weanling pigs J Anim Sci, July 1, 2008; 86(7): 1562 - 1572. [Abstract] [Full Text] [PDF]

				T. E. Weber and B. J. Kerr Effect of sodium butyrate on growth performance and response to lipopolysaccharide in weanling pigs J Anim Sci, February 1, 2008; 86(2): 442 - 450. [Abstract] [Full Text] [PDF]

				S. George, Y. Oh, S. Lindblom, S. Vilain, A. J. M. Rosa, D. H. Francis, V. S. Brozel, and R. S. Kaushik Lectin binding profile of the small intestine of five-week-old pigs in response to the use of chlortetracycline as a growth promotant and under gnotobiotic conditions J Anim Sci, July 1, 2007; 85(7): 1640 - 1650. [Abstract] [Full Text] [PDF]

				J. Li, D. F. Li, J. J. Xing, Z. B. Cheng, and C. H. Lai Effects of {beta}-glucan extracted from Saccharomyces cerevisiae on growth performance, and immunological and somatotropic responses of pigs challenged with Escherichia coli lipopolysaccharide J Anim Sci, September 1, 2006; 84(9): 2374 - 2381. [Abstract] [Full Text] [PDF]

				E. D. Reid, P. S. Erickson, S. Hodgdon, E. Lennon, and P. C. W. Tsang Chlortetracycline supplementation of yearling dairy heifers J Anim Sci, September 1, 2006; 84(9): 2406 - 2409. [Abstract] [Full Text] [PDF]

				B. J. Johnson, S. S. Dritz, K. A. Skjolaas-Wilson, T. E. Burkey, and J. E. Minton Interactive responses in gut immunity, and systemic and local changes in the insulin-like growth factor system in nursery pigs in response to Salmonella enterica serovar Typhimurium J Anim Sci, June 1, 2005; 83(13_suppl): E48 - 56. [Abstract] [Full Text] [PDF]

				M. R. Hathaway, W. R. Dayton, M. E. White, and M. S. Pampusch Effects of antimicrobials and weaning on porcine serum insulin-like growth factor binding protein levels J Anim Sci, June 1, 2003; 81(6): 1456 - 1463. [Abstract] [Full Text] [PDF]