Journal of Animal Science, Vol 74, Issue 10 2509-2522, Copyright © 1996 by American Society of Animal Science

JOURNAL ARTICLE

Intestinal effects of milkborne growth factors in neonates of agricultural importance

J. Odle, R. T. Zijlstra and S. M. Donovan
Department of Animal Science, North Carolina State University, Raleigh 27695-7621, USA.

Reduction of postnatal morbidity and mortality of mammalian neonates poses a significant challenge to agricultural and medical sciences. Because nutritional insufficiency and diarrhea represent major stressors, an understanding of factors mediating postnatal growth and development of the gastrointestinal tract is essential. This review explores the role that milkborne growth factors may play in stimulating functional development of the neonatal intestine, with emphasis on the porcine, bovine, and ovine species. Studies reporting milk concentrations and intestinal effects are reviewed, with emphasis on epidermal growth factor, insulin, and the insulin-like growth factors. Collectively, these studies suggest that milkborne growth factors may provide important regulatory signals to the neonatal intestine under both normal and pathophysiological states.

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