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Journal of Animal Science, Vol 73, Issue 7 2146-2155, Copyright © 1995 by American Society of Animal Science

JOURNAL ARTICLE

Effect of intravenous glucose infusion on metabolism of portal-drained viscera in sheep fed a cereal/straw-based diet

J. Balcells, C. J. Seal and D. S. Parker
Department of Biological and Nutritional Sciences, Faculty of Agriculture and Biological Sciences, University of Newcastle upon Tyne, U.K.

This experiment investigated the effect of intrajugular infusion of glucose on whole-body glucose metabolism and the absorption of nutrients by the portal-drained viscera of four Suffolk-cross sheep, average BW 46 +/- 7 kg, fed a cereal/straw-based pelleted diet. Each sheep received by random allocation 0 (control), 1.0, or 2.0 mg of glucose.kg BW-1.min-1 for 8 h infused into the jugular vein. Glucose irreversible loss rate, measured by simultaneous infusion of 6-[3H]-glucose, increased approximately stoichiometrically during glucose infusion (.51, .75, and 1.09 error mean square [EMS] .032 mmol/min for control, 1.0, and 2.0 mg of glucose infused.kg BW-1.min-1, respectively). Utilization of glucose increased in portal tissues (P = .089) as a result of glucose infusion (.17, .18, and .33 EMS .008 mmol/min) and was a constant proportion of glucose irreversible loss (.28). Portal blood flow was not affected by glucose infusion (overall mean 1.13 L/min EMS .034). Net portal absorption of acetate increased during glucose infusion although ruminal VFA concentrations were not affected. In contrast, net free amino acid absorption by portal-drained tissues was reduced during glucose infusion (291, 115, and 4 EMS 33,816 mumol/min, P = .054). These results show that metabolism of nutrients across the gut wall is influenced by glucose availability to gastrointestinal tissues and affects the pattern of nutrients available to the liver and peripheral tissues.


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M. Oba, R. L. Baldwin VI, and B. J. Bequette
Oxidation of glucose, glutamate, and glutamine by isolated ovine enterocytes in vitro is decreased by the presence of other metabolic fuels
J Anim Sci, February 1, 2004; 82(2): 479 - 486.
[Abstract] [Full Text] [PDF]


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Copyright © 1995 by the American Society of Animal Science.