J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spiers, D. E.
Right arrow Articles by Ellersieck, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spiers, D. E.
Right arrow Articles by Ellersieck, M. R.

Journal of Animal Science, Vol 73, Issue 7 1954-1961, Copyright © 1995 by American Society of Animal Science

JOURNAL ARTICLE

Temperature-dependent responses of rats to ergovaline derived from endophyte-infected tall fescue

D. E. Spiers, Q. Zhang, P. A. Eichen, G. E. Rottinghaus, G. B. Garner and M. R. Ellersieck
Animal Sciences Unit, University of Missouri-Columbia 65211, USA.

Ergovaline, found in Acremonium coenophialum-infected tall fescue, is considered to be responsible for many symptoms associated with fescue toxicosis. Rats were tested to determine time-related thermoregulatory responses to acute treatment with ergovaline during specific thermal challenges. Isolated ergovaline was administered to rats (15 micrograms/kg body mass, i.p.) at controlled ambient temperatures (Ta) of 7 to 9 degrees C (cold) and 31 to 33 degrees C (hot). Treatment at cold Ta resulted in a decrease in rectal temperature (Tre) from 38.0 to 37.0 degrees C at 50 min after injection (P < .05) without complete return to preinjection value at 100 min. Tail temperature (Ttail) exhibited a concomitant 1C degree decrease (P < .05) after ergovaline injection at cold Ta. Also, metabolic heat production decreased from 15.7 to 11.7 W/kg at 20 min after injection of ergovaline (P < .05), with return to normal value at 40 min after injection. Injection of ergovaline at hot Ta increased Tre from 39.0 to 40.6 degrees C at 80 min after injection (P < .05), with no return to preinjection value at 100 min. This was attributed to a reduction in heat transfer across the tail as indicated by the decrease in Ttail from 37.1 to 36.4 degrees C at 40 min after injection (P < .05) and an initial increase in metabolic heat production from 8.4 to 9.4 W/kg at 3 min after injection (P < .05). Ambient temperature was found to be a major determinant of ergovaline response, which included alterations in both thermogenic and thermolytic mechanisms that control thermal balance.


This article has been cited by other articles:


Home page
 J ANIM SCIHome page
G. E. Aiken, B. H. Kirch, J. R. Strickland, L. P. Bush, M. L. Looper, and F. N. Schrick
Hemodynamic responses of the caudal artery to toxic tall fescue in beef heifers
J Anim Sci, September 1, 2007; 85(9): 2337 - 2345.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
R. S. Settivari, S. Bhusari, T. Evans, P. A. Eichen, L. B. Hearne, E. Antoniou, and D. E. Spiers
Genomic analysis of the impact of fescue toxicosis on hepatic function
J Anim Sci, May 1, 2006; 84(5): 1279 - 1294.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
D. E. Spiers, P. A. Eichen, and G. E. Rottinghaus
A model of fescue toxicosis: Responses of rats to intake of endophyte-infected tall fescue
J Anim Sci, June 1, 2005; 83(6): 1423 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
M. S. Gadberry, T. M. Denard, D. E. Spiers, and E. L. Piper
Effects of feeding ergovaline on lamb performance in a heat stress environment
J Anim Sci, June 1, 2003; 81(6): 1538 - 1545.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Society of Animal Science.