J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Azain, M. J.
Right arrow Articles by Kasser, T. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Azain, M. J.
Right arrow Articles by Kasser, T. R.

Journal of Animal Science, Vol 73, Issue 4 1019-1029, Copyright © 1995 by American Society of Animal Science

JOURNAL ARTICLE

Comparison of daily versus continuous administration of somatotropin on growth rate, feed intake, and body composition in intact female rats

M. J. Azain, T. J. Roberts, R. J. Martin and T. R. Kasser
Animal and Dairy Science Department, University of Georgia, Athens 30602, USA.

The response to continuous delivery or daily bolus injection of porcine somatotropin (pST) was compared in mature, pituitary-intact female rats (225 g). Growth rate in control rats was approximately 1 g/d over the 14-d study. There was a dose-dependent (0, .4, 1.2, and 3.6 mg of pST/d; P < .001) increase in rate of gain with an interaction (P < .001) of dose and mode of delivery. The slope of the dose-response curve for growth rate was linear on a logarithmic scale for both modes of delivery but was greater for continuous delivery. At the low dose (.4 mg/d) pST stimulated gain (21.7 g/14 d above control, P < .05) when administered by daily injection but failed to stimulate gain (6.0 g/14 d above control, NS) when delivered continuously. At the high dose (3.6 mg/d), gain (above that in control rats) was 49.1 and 79.7 g/14 d for daily and continuous delivery; the two modes were different (P < .05) from each other. Feed intake and liver weights were also stimulated by pST in a dose-dependent manner. The increase in liver size was accompanied by a dose-dependent increase in liver DNA, indicative of an increase in cell number. Increased carcass gain was largely accounted for by increased carcass protein accretion. Rates of carcass lipid accretion were lower than those for protein accretion and were further decreased by pST, particularly by the high dose administered by continuous delivery, where a negative lipid accretion value was observed. Circulating IGF-I was increased by pST (P < .001) but was not affected by the mode of delivery. The results demonstrate that the increased gain observed in mature rats is largely due to lean tissue accretion and is accompanied by an increase in feed intake.


This article has been cited by other articles:


Home page
 J EndocrinolHome page
B. S Amorim, C. B Ueta, B. C G Freitas, R. J Nassif, C. H. d. A. Gouveia, M. A Christoffolete, A. S Moriscot, C. L. Lancelloti, F. Llimona, H. V. Barbeiro, et al.
A TR{beta}-selective agonist confers resistance to diet-induced obesity
J. Endocrinol., November 1, 2009; 203(2): 291 - 299.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. Egecioglu, M. Bjursell, A. Ljungberg, S. L. Dickson, J. J. Kopchick, G. Bergstrom, L. Svensson, J. Oscarsson, J. Tornell, and M. Bohlooly-Y
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice
Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E317 - E325.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. J. Azain, J. R. Broderson, and R. J. Martin
Effect of Long-Term Somatotropin Treatment on Body Composition and Life Span in Aging Obese Zucker Rats
Experimental Biology and Medicine, January 1, 2006; 231(1): 76 - 83.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Olsson, M. Bohlooly-Y, S. M. Fitzgerald, F. Frick, A. Ljungberg, B. Ahren, J. Tornell, G. Bergstrom, and J. Oscarsson
Bovine Growth Hormone Transgenic Mice Are Resistant to Diet-Induced Obesity but Develop Hyperphagia, Dyslipidemia, and Diabetes on a High-Fat Diet
Endocrinology, February 1, 2005; 146(2): 920 - 930.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Bohlooly-Y, B. Olsson, C. E.G. Bruder, D. Linden, K. Sjogren, M. Bjursell, E. Egecioglu, L. Svensson, P. Brodin, J. C. Waterton, et al.
Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia
Diabetes, January 1, 2005; 54(1): 51 - 62.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. G. Clark, G. B. Thomas, D. L. Mortensen, W. B. Won, Y. H. Ma, E. E. Tomlinson, K. M. Fairhall, and I. C. A. F. Robinson
Growth Hormone Secretagogues Stimulate the Hypothalamic-Pituitary-Adrenal Axis and Are Diabetogenic in the Zucker Diabetic Fatty Rat
Endocrinology, October 1, 1997; 138(10): 4316 - 4323.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
T. J. Roberts and M. J. Azain
Somatotropin Treatment Reduces Energy Intake without Altering Protein Intake in Pigs Selecting between High and Low Protein Diets
J. Nutr., October 1, 1997; 127(10): 2047 - 2053.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Society of Animal Science.