Journal of Animal Science, Vol 73, Issue 11 3445-3454, Copyright © 1995 by American Society of Animal Science

CLINICAL TRIAL

Efficacy of laidlomycin propionate to reduce ruminal acidosis in cattle

M. L. Bauer, D. W. Herold, R. A. Britton, R. A. Stock, T. J. Klopfenstein and D. A. Yates
University of Nebraska, Lincoln 68583-0908, USA.

Three trials were conducted to evaluate the efficacy of laidlomycin propionate (LP) to reduce the incidence and severity of ruminal acidosis in cattle fed high-grain finishing diets. In each trial, LP was fed at 0, 6, or 12 mg/kg of diet DM. In two acidosis-challenge trials, ruminally fistulated steers were fed (DM basis) a 50% concentrate diet and then fed a 95% concentrate diet at a specific intake (2.75% BW) or steers were dosed intraruminally with a 100% concentrate diet. Laidlomycin propionate did not alter ruminal pH or total acid concentrations, but in Trial 1 the 6 mg/kg level altered (P < .10) the molar proportions of the acids, increasing total ruminal VFA and decreasing ruminal lactate. In Trial 3, a finishing trial, LP reduced (P < .10) intake day-to-day variation of individually fed steers during a 13-d adaptation period from a 65 to a 100% concentrate diet, suggesting reduced incidence of subacute acidosis. Feed intake was lower (P < .05) during the first 13 d of the trial due to LP but was not affected over the entire trial. Laidlomycin propionate improved feed efficiency (gain/feed) when calculated on a live weight basis (linear, P = .05) or carcass weight basis (linear, P = .20). Laidlomycin propionate does not prevent ruminal acidosis, but it may reduce the severity of ruminal acidosis during adaptation to a 100% concentrate diet.

This article has been cited by other articles:

				R. E. Larrain, D. M. Schaefer, S. C. Arp, J. R. Claus, and J. D. Reed Finishing steers with diets based on corn, high-tannin sorghum, or a mix of both: Feedlot performance, carcass characteristics, and beef sensory attributes J Anim Sci, June 1, 2009; 87(6): 2089 - 2095. [Abstract] [Full Text] [PDF]

				M. Blanch, S. Calsamiglia, N. DiLorenzo, A. DiCostanzo, S. Muetzel, and R. J. Wallace Physiological changes in rumen fermentation during acidosis induction and its control using a multivalent polyclonal antibody preparation in heifers J Anim Sci, May 1, 2009; 87(5): 1722 - 1730. [Abstract] [Full Text] [PDF]

				J. W. Golden, M. S. Kerley, and W. H. Kolath The relationship of feeding behavior to residual feed intake in crossbred Angus steers fed traditional and no-roughage diets J Anim Sci, January 1, 2008; 86(1): 180 - 186. [Abstract] [Full Text] [PDF]

				D. W. Bevans, K. A. Beauchemin, K. S. Schwartzkopf-Genswein, J. J. McKinnon, and T. A. McAllister Effect of rapid or gradual grain adaptation on subacute acidosis and feed intake by feedlot cattle J Anim Sci, May 1, 2005; 83(5): 1116 - 1132. [Abstract] [Full Text] [PDF]

				J. W. Schroeder Optimizing the Level of Wet Corn Gluten Feed in the Diet of Lactating Dairy Cows J Dairy Sci, March 1, 2003; 86(3): 844 - 851. [Abstract] [Full Text] [PDF]

				K. S. Schwartzkopf-Genswein, K. A. Beauchemin, D. J. Gibb, D. H. Crews Jr., D. D. Hickman, M. Streeter, and T. A. McAllister Effect of bunk management on feeding behavior, ruminal acidosis and performance of feedlot cattle: A review J Anim Sci, February 1, 2003; 81(14_suppl_2): E149 - 158. [Abstract] [Full Text] [PDF]