Journal of Animal Science, Vol 73, Issue 11 3402-3408, Copyright © 1995 by American Society of Animal Science

JOURNAL ARTICLE

The pattern of the circadian rhythm of pancreatic secretion in fed pigs

M. J. Thaela, S. G. Pierzynowski, M. S. Jensen, K. Jakobsen, B. R. Westrom and B. W. Karlsson
Department of Animal Physiology, University of Lund, Sweden.

The pattern of the circadian rhythm of pancreatic secretion was studied in four 6- to 7-wk-old intact male pigs that were kept in metabolic cages under 12 h light:12 h dark cycles and fed three times a day at 0800, 1500, and 2200. Three 24-h collections of pancreatic juice and blood were begun at 0800 every 2nd day during 5 d. A biphasic pattern of the exocrine pancreas was detected. Secretions during the first phase (postprandial peak) contained large amounts of protein and enzymes, and secretions appeared immediately after feed ingestion. Secretions during the second phase (between meals) had lesser amounts (P < .001) of protein and enzymes, but were of longer duration (P < .001). The output of protein and trypsin activity were generally correlated (P < .001) with each other, but the correlation of either with the volume outflow were small. However, these variables were correlated (P < .01) with the volume outflow at night during the second phase. Plasma concentrations of insulin and glucose increased after each meal, but the increase was significant (P < .05) only for insulin. Insulin and glucose concentrations were correlated (P < .01) with each other after the meals at 0800 and 1500. The results indicated a biphasic pattern of the exocrine pancreas and a monophasic pattern of the endocrine pancreas in pigs. The regulation of these patterns seems to vary during the 24-h period. Furthermore, feed enhanced secretion, but it did not seem to be the only factor controlling the circadian pattern.

This article has been cited by other articles:

				J. J. G. C. van den Borne, B. R. Westrom, D. Kruszewska, J. A. M. Botermans, J. Svendsen, J. Wolinski, and S. G. Pierzynowski Exocrine pancreatic secretion in pigs fed sow's milk and milk replacer, and its relationship to growth performance J Anim Sci, February 1, 2007; 85(2): 404 - 412. [Abstract] [Full Text] [PDF]

				J. Keller and P. Layer Circadian pancreatic enzyme pattern and relationship between secretory and motor activity in fasting humans J Appl Physiol, August 1, 2002; 93(2): 592 - 600. [Abstract] [Full Text] [PDF]

				M. S. Hedemann, A. R. Pedersen, and R. M. Engberg Exocrine Pancreatic Secretion Is Stimulated in Piglets Fed Fish Oil Compared with Those Fed Coconut Oil or Lard J. Nutr., December 1, 2001; 131(12): 3222 - 3226. [Abstract] [Full Text] [PDF]

				S. Jakob, R. Mosenthin, R. Zabielski, C. Rippe, M. S. Winzell, U. Gacsalyi, D. Laubitz, E. Grzesiuk, and S. G. Pierzynowski Fats Infused Intraduodenally Affect the Postprandial Secretion of the Exocrine Pancreas and the Plasma Concentration of Cholecystokinin but Not of Peptide YY in Growing Pigs J. Nutr., October 1, 2000; 130(10): 2450 - 2455. [Abstract] [Full Text]