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Journal of Animal Science, Vol 72, Issue 9 2431-2440, Copyright © 1994 by American Society of Animal Science

JOURNAL ARTICLE

Administration of porcine somatotropin by a sustained-release implant: effect on follicular growth, concentrations of steroids and insulin-like growth factor I, and insulin-like growth factor binding protein activity in follicular fluid of control, lean, and obese gilts

S. E. Echternkamp, L. J. Spicer, J. Klindt, R. K. Vernon, J. T. Yen and F. C. Buonomo
U. S. Meat Animal Res. Center, Clay Center, NE 68933.

Prepubertal gilts of control (n = 30), obese (n = 30), or lean (n = 29) genetic lines were implanted with no, one, or two implants of porcine somatotropin (pST, each delivers 2 mg/d) for 6 wk starting at 160 d of age to determine whether pST affects ovarian function. At 4 mg/d, pST increased (P < .01) numbers of 4.0- to 6.9-mm (medium) follicles but not (P > .10) numbers of 1.0- to 3.9-mm (small) follicles per gilt. Both doses of pST increased (P < .01) serum and follicular fluid (FFL) concentrations of IGF-I and activity of IGF binding protein (IGFBP)-3 and 36-kDa IGFBP in all three lines; IGFBP-3 was the predominant IGFBP. In comparison, binding activity of IGFBP-2 was decreased (P < .01) in serum by 4 mg of pST but increased (P < .05) in FFL by 4 mg of pST. Lean gilts had lower (P < .05) serum concentrations of IGF-I and less (P < .05) total binding activity of IGFBP than control and obese gilts. Concentrations of estradiol in FFL of small and medium follicles tended (P < .08) to be increased by 2 mg/d of pST, whereas FFL concentrations of progesterone were unaffected by pST. Obese and control gilts had twofold greater (P < .05) FFL progesterone concentrations than lean gilts. We conclude that sustained-release implants of pST can stimulate follicular growth, increase concentrations of IGF-I in serum and FFL, and increase IGFBP activity in serum of genetically divergent lines of gilts without an adverse effect on ovarian function.


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Copyright © 1994 by the American Society of Animal Science.