J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhou, W.
Right arrow Articles by Wong, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, W.
Right arrow Articles by Wong, E. A.

Journal of Animal Science, Vol 72, Issue 9 2395-2403, Copyright © 1994 by American Society of Animal Science

JOURNAL ARTICLE

Stimulation of growth by intravenous injection of copper in weanling pigs

W. Zhou, E. T. Kornegay, M. D. Lindemann, J. W. Swinkels, M. K. Welten and E. A. Wong
Department of Animal Science, Virginia Polytechnic Institute and State University, Blacksburg 24061.

This study was conducted to examine whether Cu could exert its growth-promoting effect when injected, rather than being fed, and thus bypass the gastrointestinal tract. In two 18-d experiments, pigs were injected every 2 d with a Cu histidinate or histidine solution. Amounts of Cu injected were calculated to simulate varying absorption rates in pigs fed 250 ppm of dietary Cu. In Exp. 1, 44 pigs were randomly assigned to four groups of 11 pigs each. Pigs were injected with four levels of Cu histidinate (0, 5, 10, and 15% estimated apparent absorption coefficients based on calculated feed intake). Average daily gain responded quadratically (P < .05) to levels of Cu histidinate; maximum growth was seen in the 5% group. At d 6, serum mitogenic activity also exhibited a similar quadratic response (P < .05). In Exp. 2, estimated Cu absorptions of 0, 2, 4, 6, and 8% were tested. Forty-five pigs were randomly assigned to five groups of nine pigs each and injected as in Exp. 1. Both ADG and serum mitogenic activity displayed a quadratic response (P < .05); the maximum response was seen in the 4% group. Liver Cu content, superoxide dismutase activity, and serum Cu concentrations were linearly increased (P < .05) with increasing dosage of Cu in both Exp. 1 and 2. Also, brain Cu content linearly increased (P < .05) with increasing dosage of Cu in both Exp. 1 and 2. Also, brain Cu hormone mRNA concentrations in Exp. 2 were not significantly influenced by treatments.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J ANIM SCIHome page
J. Zhao, A. F. Harper, M. J. Estienne, K. E. Webb Jr., A. P. McElroy, and D. M. Denbow
Growth performance and intestinal morphology responses in early weaned pigs to supplementation of antibiotic-free diets with an organic copper complex and spray-dried plasma protein in sanitary and nonsanitary environments
J Anim Sci, May 1, 2007; 85(5): 1302 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
M. E. Davis, C. V. Maxwell, D. C. Brown, B. Z. de Rodas, Z. B. Johnson, E. B. Kegley, D. H. Hellwig, and R. A. Dvorak
Effect of dietary mannan oligosaccharides and(or) pharmacological additions of copper sulfate on growth performance and immunocompetence of weanling and growing/finishing pigs
J Anim Sci, November 1, 2002; 80(11): 2887 - 2894.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the American Society of Animal Science.