J. Anim Sci.
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Journal of Animal Science, Vol 72, Issue 2 421-427, Copyright © 1994 by American Society of Animal Science

JOURNAL ARTICLE

Diet effects and ontogeny of alterations of circulating insulin-like growth factor binding proteins in newborn dairy calves

T. C. Skaar, C. R. Baumrucker, D. R. Deaver and J. W. Blum
Department of Dairy and Animal Science, Pennsylvania State University, University Park 16802.

Insulin-like growth factors (IGF) are important growth regulators in many species, and their effects are influenced by their association with IGF-binding proteins (IGFBP). The objectives of this study were to characterize the ontogeny of the blood plasma IGFBP in calves and to determine the effect of dietary IGF-I neonatal plasma IGFBP. Plasma from newborn and 7-d-old male calves fed milk replacer, milk replacer + recombinant human IGF-I (rhIGF-I), or colostrum for 2 d followed by milk replacer was analyzed for IGFBP by ligand blot analysis. In addition, plasma samples from 1-, 12-, 24-, and 45-wk-old male calves were analyzed for IGFBP and IGF-I. Newborn and 7-d-old calf plasma contained IGFBP with M(r) of 26, 34, and 42 to 48 kDa. These profiles were not affected by the dietary treatments; however, a slight increase in the 34-kDa IGFBP and a slight decrease in the 26- and 42- to 48-kDa IGFBP were detected from birth to 7 d of age. The 34-kDa was confirmed to be bovine IGFBP-2 by immunoblot and the 42- to 48-kDa is likely IGFBP-3. The 29-, 31-, and 42- to 48-kDa IGFBP increased between 1 and 45 wk of age. Similarly, plasma IGF-I concentrations were increased from 49.7 to 449.7 ng/mL in plasma from calves from 1 to 45 wk of age. In contrast, the 34-kDa IGFBP increased from 1 to 12 wk but then gradually decreased from 12 to 45 wk, whereas the 26-kDa IGFBP did not change.(ABSTRACT TRUNCATED AT 250 WORDS)


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Copyright © 1994 by the American Society of Animal Science.