| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Animal Science, Vol 72, Issue 11 2812-2819, Copyright © 1994 by American Society of Animal Science
JOURNAL ARTICLE |
J. R. Knapp, W. Y. Chen, N. D. Turner, F. M. Byers and J. J. Kopchick
Edison Biotechnology Institute, Ohio University, Athens 45701.
The objectives of this study were to determine growth rates, feed intakes, feed efficiencies, and chemical composition of mice from three transgenic lines in 10-d periods from weaning to near maturity. Lines M4, M11, and G119K express bovine somatotropin (bST) mutations E117L, L121P-E126G, and G119K and display phenotypes of large, near normal, and small body size, respectively. M4 mice were 28% larger at 28 d and 84% larger at 68 d than non-transgenic control (NTC) mice. M11 mice were the same size at 28 d as NTC but were 25% larger at 68 d. G119K mice were 34% and 25% smaller than NTC at 28 and 68 d, respectively. Growth rates of G119K mice and NTC were similar, whereas growth rates of M11 and M4 mice were increased (P < .05). Feed intakes of M4 and M11 mice were greater than those of NTC mice (P < .05), whereas feed intakes of G119K mice were lower than those of NTC mice (P < .05). Feed efficiency (gain/feed) was improved in M4 and M11 mice (P < .05) and not altered in G119K mice compared to that of NTC mice (P > .05). Chemical composition was also altered by expression of bST analogs in transgenic mice. G119K and M4 mice had increased body fat percentages and decreased body protein percentages in comparison to M11 and NTC mice (P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  A. J. Palmer, M.-Y. Chung, E. O. List, J. Walker, S. Okada, J. J. Kopchick, and D. E. Berryman Age-Related Changes in Body Composition of Bovine Growth Hormone Transgenic Mice Endocrinology, March 1, 2009; 150(3): 1353 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Stevenson, B. A. J. Evans, E. F. Gevers, C. Elford, R. W. J. McLeod, M. J. Perry, M. M. El-Kasti, K. T. Coschigano, J. J. Kopchick, S. L. Evans, et al. Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency? Am J Physiol Endocrinol Metab, January 1, 2009; 296(1): E147 - E156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.R. Smid, J.E. Rowland, W.G. Young, K.T. Coschigano, J.J. Kopchick, and M.J. Waters Mouse Molar Dentin Size/Shape is Dependent on Growth Hormone Status Journal of Dental Research, May 1, 2007; 86(5): 463 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Davies, E. F. Gevers, A. E. Stevenson, K. T. Coschigano, M. M. El-Kasti, M. J. Bull, C. Elford, B. A. J. Evans, J. J. Kopchick, and T. Wells Adiposity profile in the dwarf rat: an unusually lean model of profound growth hormone deficiency Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1483 - E1494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Berryman, E. O. List, D. T. Kohn, K. T. Coschigano, R. J. Seeley, and J. J. Kopchick Effect of Growth Hormone on Susceptibility to Diet-Induced Obesity Endocrinology, June 1, 2006; 147(6): 2801 - 2808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Smaniotto, V. de Mello-Coelho, D. M. S. Villa-Verde, J.-M. Pleau, M.-C. Postel-Vinay, M. Dardenne, and W. Savino Growth Hormone Modulates Thymocyte Development in Vivo through a Combined Action of Laminin and CXC Chemokine Ligand 12 Endocrinology, July 1, 2005; 146(7): 3005 - 3017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. E. Meyer, D. Korthaus, W. Jagla, E. Cornali, J. Grosse, H. Fuchs, M. Klingenspor, S. Roemheld, M. Tschop, G. Heldmaier, et al. A Novel Missense Mutation in the Mouse Growth Hormone Gene Causes Semidominant Dwarfism, Hyperghrelinemia, and Obesity Endocrinology, May 1, 2004; 145(5): 2531 - 2541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.R. Smid, J.E. Rowland, W.G. Young, T.J. Daley, K.T. Coschigano, J.J. Kopchick, and M.J. Waters Mouse Cellular Cementum is Highly Dependent on Growth Hormone Status Journal of Dental Research, January 1, 2004; 83(1): 35 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Frost and C. H. Lang Alteration of somatotropic function by proinflammatory cytokines J Anim Sci, January 1, 2004; 82(13_suppl): E100 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Coschigano, A. N. Holland, M. E. Riders, E. O. List, A. Flyvbjerg, and J. J. Kopchick Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span Endocrinology, September 1, 2003; 144(9): 3799 - 3810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, J. R. Knapp, and J. J. Kopchick Enlargement of Interscapular Brown Adipose Tissue in Growth Hormone Antagonist Transgenic and in Growth Hormone Receptor Gene-Disrupted Dwarf Mice Experimental Biology and Medicine, February 1, 2003; 228(2): 207 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, B. Kelder, and J. J. Kopchick Identification, Isolation, and Cloning of Growth Hormone (GH)-Inducible Interscapular Brown Adipose Complementary Deoxyribonucleic Acid from GH Antagonist Mice Endocrinology, July 1, 2001; 142(7): 2937 - 2945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Turner, J. R. Knapp, F. M. Byers, and J. J. Kopchick Physical and Mechanical Characteristics of Tibias from Transgenic Mice Expressing Mutant Bovine Growth Hormone Genes Experimental Biology and Medicine, February 1, 2001; 226(2): 133 - 139. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. D. Turner, J. R. Knapp, F. M. Byers, and J. J. Kopchick Expression of Mutant Bovine Growth Hormone Genes in Mice Perturbs Age-Related Nutrient Utilization Patterns J. Nutr., March 1, 1998; 128(3): 520 - 524. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
