J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Azain, M. J.
Right arrow Articles by Baile, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Azain, M. J.
Right arrow Articles by Baile, C. A.

Journal of Animal Science, Vol 71, Issue 2 384-392, Copyright © 1993 by American Society of Animal Science

JOURNAL ARTICLE

Comparison of the growth-promoting properties of daily versus continuous administration of somatotropin in female rats with intact pituitaries

M. J. Azain, T. R. Kasser, M. J. Sabacky and C. A. Baile
Animal and Dairy Science Department, University of Georgia, Athens 30602.

The effect of dose and mode of delivery of recombinant bovine (rbST) or porcine somatotropin (rpST) on the growth rate of female rats with intact pituitaries was investigated in a series of experiments. The overall objective of these studies was to compare the relationship of dose and mode of delivery on the growth response to somatotropin. The equivalence of rbST and rpST in stimulation of growth was demonstrated. In an initial study, treatment of rats with 0, .67 (3 mg/kg), or 2.0 mg/d (9 mg/kg) of rbST for 28 d resulted in ADG of .8, 2.6, and 3.8 g/d (P < .0001, SEM .1 g). A log-linear dose response to rbST in the range of .07 to 32 mg/d (.3 to 145 mg/kg) for the stimulation of gain was observed. Continuous delivery of rpST in bicarbonate buffer was achieved using osmotic pumps. Sustained, log-linear growth for doses of 0, .5, 1, 2, and 4 mg of rpST/d for 28 d was demonstrated. In a direct comparison of bolus injection and continuous delivery at doses of 0, .22, .67, 2.0, and 6.0 mg of rpST/d, a significant difference in slope (P < .0001) of the modes of delivery was observed; continuous delivery had a greater slope. Depending on the dose administered, bolus injection was either more (< .67 mg/d) or less efficacious (> .67 mg/d) than continuous delivery in its ability to stimulate growth in female rats with intact pituitaries. It is hypothesized that the difference in the slope of the dose-response curves can be accounted for by the animal's ability to utilize the hormone effectively.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
M. J. Gahl, N. J. Benevenga, and T. D. Crenshaw
Rates of Lysine Catabolism Are Inversely Related to Rates of Protein Synthesis When Measured Concurrently in Adult Female Rats Induced to Grow at Different Rates
J. Nutr., September 1, 1998; 128(9): 1503 - 1511.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by the American Society of Animal Science.