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Journal of Animal Science, Vol 70, Issue 8 2556-2561, Copyright © 1992 by American Society of Animal Science

JOURNAL ARTICLE

Bioavailability of vitamin E compounds in lambs

N. Hidiroglou, L. R. McDowell, A. M. Papas, M. Antapli and N. S. Wilkinson
Department of Surgery, East Tennessee State University, Johnson City 37604.

A study was carried out to assess the bioavailabilities of several forms of vitamin E in lambs. A total of 40 lambs was allotted to eight dietary groups of five each and supplemented or not daily for 60 d with equimolar amounts of different vitamin E compounds as follows: 1) control, no supplemental vitamin E, 2) DL-alpha-tocopheryl acetate, 3) D-alpha-tocopheryl acetate, 4), D-alpha-tocopheryl succinate, 5) D-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS), 6) DL-alpha-tocopheryl nicotinate, 7) DL-alpha-tocopheryl nicotinate+ TPGS, or 8) D-alpha-tocopheryl acetate + TPGS. During these 60 d, serum alpha-tocopherol concentrations in the control lambs remained constant and lower (P less than .05) than in lambs that received all treatments. Various indices of bioavailability, including Cmax-C(i) (concentration maximum-concentration initial), Ct-C(i) (concentration terminal-concentration initial), areas under the serum concentrations profiles, and pooled increment were higher (P less than .05) with D-alpha-tocopheryl acetate+ TPGS than in the other groups, suggesting a synergism between these forms. No such effect was observed between nicotinate and TPGS. For the TPGS, a water-soluble form of vitamin E, the indices of bioavailability were lower (P less than .05) than for the other groups. D-alpha-tocopheryl acetate resulted in a bioavailability that outranked all the other forms of vitamin E, except those of D-alpha-tocopheryl acetate + TPGS. A slightly higher bioavailability index was observed for D-alpha-tocopheryl succinate than for DL-alpha-tocopheryl nicotinate.(ABSTRACT TRUNCATED AT 250 WORDS)


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S. K. Jensen, R. M. Engberg, and M. S. Hedemann
All-rac-{alpha}-Tocopherol Acetate Is a Better Vitamin E Source than all-rac-{alpha}-Tocopherol Succinate for Broilers
J. Nutr., July 1, 1999; 129(7): 1355 - 1360.
[Abstract] [Full Text]


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Copyright © 1992 by the American Society of Animal Science.