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Journal of Animal Science, Vol 70, Issue 5 1382-1388, Copyright © 1992 by American Society of Animal Science

JOURNAL ARTICLE

Passive immunization with antiserum to adrenocorticotropin increases weight gain in normal female rats

M. N. Sillence, M. R. Jones, P. Lowry and J. R. Bassett
Tropical Cattle Research Centre, CSIRO Division of Tropical Animal Production, Rockhampton, Queensland, Australia.

Passive immunization against ACTH was used to test the hypothesis that growth in female rats is constrained by physiological concentrations of glucocorticoids. When animals were stressed by 15-min exposure to ether before blood sampling by cardiac puncture, serum concentrations of corticosterone were lower (P less than .05) in immunized rats than in stressed controls. The maximum effect was apparent 2 h after injection of ACTH antiserum, and no effect was apparent 6 h after injection. To examine the effects of ACTH immunization on growth, rats received daily injections of either saline, sheep immunoglobulin G, or ACTH antiserum, 2 h before the afternoon peak in plasma concentrations of corticosterone. After 7 d of treatment, rats treated with ACTH antiserum had gained 37% more body weight than saline-injected controls, and this effect was accompanied by a 59% reduction in peak plasma concentrations of corticosterone. Immunoglobulin G purified from normal sheep serum had no effect on weight gain. It is concluded that growth rate in normal female rats can be stimulated through the suppression of adrenal activity.


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C. Lee, L. R. Giles, W. L. Bryden, J. A. Downing, D. C. Collins, and P. C. Wynn
The effect of active immunization against adrenocorticotropic hormone on cortisol, {beta}-endorphin, vocalization, and growth in pigs
J Anim Sci, October 1, 2005; 83(10): 2372 - 2379.
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Copyright © 1992 by the American Society of Animal Science.