J. Anim Sci.
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Journal of Animal Science, Vol 70, Issue 4 1220-1226, Copyright © 1992 by American Society of Animal Science

JOURNAL ARTICLE

Biokinetics and biliary excretion of radiotocopherol administered orally to sheep

M. Hidiroglou and M. Ivan
Animal Research Centre, Agriculture Canada, Ottawa, Ontario.

Four adult sheep were given .4 microCi/kg of BW of D-alpha[5-Me-3H]tocopherol orally. Plasma alpha-tocopherol specific activities were measured serially during a 72-h period, after which the sheep were killed. The disposition kinetics were best described by the use of a two-compartment model. The radiotocopherol had a slow distribution phase followed by a relatively slow elimination phase. During the 72-h period of serial monitoring the peak plasma specific activities were observed between 32 to 48 h. At slaughter (72 h after dosing) tissue radioactivity distribution indicated a high rate of accumulation in some glandular organs such as the liver and adrenals. Identification of radioactive components excreted in bile, using HPLC or thin-layer chromatography, showed that unchanged radiotocopherol was present only at very low concentrations (less than 3% of the total recovered radioactivity).




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Copyright © 1992 by the American Society of Animal Science.