J. Anim Sci.
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Journal of Animal Science, Vol 70, Issue 11 3627-3634, Copyright © 1992 by American Society of Animal Science

JOURNAL ARTICLE

Pharmacokinetics in immature animals: a review

J. F. Nouws
Farma Research BV, Nijmegen, The Netherlands.

Differences in drug pharmacokinetics between newborn and adult mammals are reviewed. The pharmacokinetic alterations during the maturation process are related to changes in the pattern of absorption, distribution, metabolism, and renal excretion. The most pronounced feature in neonates vs adults is the prolonged elimination half-life of drugs. The main factors causing delayed elimination are under-developed renal clearance and immature metabolism of drugs. Special attention has to be paid to central nervous system depressants and to drugs that are extensively metabolized because they will accumulate with repeated dosing of newborn animals.




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Copyright © 1992 by the American Society of Animal Science.