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Relationship of Tryptophane to Nicotinic Acid in the Feeding of Growing Pigs

United States Department of Agriculture

Abstract

The results of the experiment reported in this paper may be summarized as follows:

1. A deficiency overcome by nicotinic acid was produced in pigs receiving a diet containing 40 percent of corn supplemented with casein and other purified materials to obtain a protein content of 21.5 percent by analysis and further supplemented with essential vitamins other than nicotinic acid.
   
2. The deficiency produced by a similar diet of lower tryptophane content was partly but apparently not completely prevented by additions of nicotinic acid.
   
3. The deficiency produced by the low nicotinic acid, low-tryptophane diet, except for some diarrhea, was prevented by the addition of d-l-tryptophane at the rate of .25 percent of the diet.
   
4. Nicotinic acid appeared not to be completely effective as a substitute for tryptophane, but tryptophane appeared to be, in large measure at least, a satisfactory substitute for nicotinic acid. More cannot be said, since the corn in the diet to which tryptophane was added supplied the experimental animals with about .35 mg. of nicotinic acid per kilogram of live weight per day.