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Absorption and Elimination of Thiouracil in Ruminants¹

Michigan State College²

Abstract

The absorption and elimination of thiouracil was studied in calves and goats following oral and subcutaneous administrations.

Maximum blood plasma thiouracil concentrations were reached in 4 to 8 hours following oral administration and in 2 to 4 hours following subcutaneous administration. Over the range studied, blood plasma thiouracil concentrations were approximately proportional to dosage levels.

Single doses administered subcutaneously gave approximately twice the blood plasma thiouracil concentration as the same dosage level administered orally.

Essentially uniform blood plasma thiouracil concentrations were maintained in ruminants with oral and subcutaneous administration at 12 hour intervals.

Thiouracil was practically eliminated from the blood stream within 24 hours after cessation of administration.

¹ Published with the approval of the director of the Agricultural Experiment Station as journal article No. 903 (n.s.).

² Departments of Dairy, Chemistry and Physiology, East Lansing, Michigan.