J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chung, T. K.
Right arrow Articles by Baker, D. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chung, T. K.
Right arrow Articles by Baker, D. H.

Journal of Animal Science, Vol 69, Issue 7 2955-2960, Copyright © 1991 by American Society of Animal Science

JOURNAL ARTICLE

Safety of L-tryptophan for pigs

T. K. Chung, H. B. Gelberg, J. L. Dorner and D. H. Baker
Dept. of Anim. Sci., University of Illinois, Urbana 61801.

Epidemic eosinophilia-myalgia syndrome (EMS) associated with excess L-tryptophan (Trp) consumption in humans has been declared a major public health problem. The EMS problem has not been observed in pigs, nor has comprehensive pathology associated with EMS in humans been described. Experiments were therefore conducted to evaluate the pathology and effects of excess dietary L-Trp for finishing (79 to 119 kg) pigs and to determine an LD50 of Trp for pigs. In Exp. 1, addition of .1 or 1% Trp to corn-soybean meal diets had no effect on growth performance or leukocyte and relative eosinophil counts or on plasma aspartate transferase, creatine phosphokinase, and lactate dehydrogenase activities. Likewise, untoward pathological effects of Trp feeding were not observed in the animals under study. In Exp. 2, supplementing the basal diet with 0, 2, and 4% Trp caused linear (P less than .05) decreases in weight gain, feed intake, and gain:feed ratio. Mortality could not be produced by acute oral dosing in the LD50 study (Exp. 3), wherein Trp doses between 2.00 and 5.71 g/kg of BW were administered by stomach tube. Vomiting occurred at oral doses greater than 5.71 g/kg of BW. These results suggest that oral ingestion of Trp in pigs is safe and that pigs can tolerate considerable excesses of Trp.


This article has been cited by other articles:


Home page
 J ANIM SCIHome page
Y. Z. Li, B. J. Kerr, M. T. Kidd, and H. W. Gonyou
Use of supplementary tryptophan to modify the behavior of pigs
J Anim Sci, January 1, 2006; 84(1): 212 - 220.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. J. Garlick
The Nature of Human Hazards Associated with Excessive Intake of Amino Acids
J. Nutr., June 1, 2004; 134(6): 1633S - 1639S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. L Buchman
Glutamine: commercially essential or conditionally essential? A critical appraisal of the human data
Am. J. Clinical Nutrition, July 1, 2001; 74(1): 25 - 32.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
G. Sarwar and H. G. Botting
Liquid Concentrates Are Lower in Bioavailable Tryptophan than Powdered Infant Formulas, and Tryptophan Supplementation of Formulas Increases Brain Tryptophan and Serotonin in Rats
J. Nutr., September 1, 1999; 129(9): 1692 - 1697.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American Society of Animal Science.