J. Anim Sci.
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Journal of Animal Science, Vol 68, Issue 10 3322-3329, Copyright © 1990 by American Society of Animal Science

JOURNAL ARTICLE

Effects of active immunization against GnRH on LH, FSH and prolactin storage, secretion and response to their secretagogues in pony geldings

M. H. Rabb, D. L. Thompson Jr, B. E. Barry, D. R. Colborn, K. E. Hehnke and F. Garza Jr
Anim. Sci. Dept., Louisiana State University Agricultural Center, Baton Rouge 70803.

Six pony geldings were actively immunized against GnRH conjugated to bovine serum albumin (BSA) to study 1) the relative dependency of LH and FSH storage, secretion and response to GnRH analog on GnRH bioavailability and 2) the effects of reduced GnRH bioavailability on GnRH storage in the hypothalamus. Five geldings were immunized against BSA. Geldings were immunized in December and 4, 8, 14, 20, 26 and 32 wk later. Ponies immunized against GnRH had increased (P less than .01) GnRH binding in plasma within 6 wk. By June, plasma concentrations of LH and FSH in ponies immunized against GnRH had decreased (P less than .02) by 86 and 59%, respectively, relative to ponies immunized against BSA. The LH response to an injection of GnRH analog, which did not bind to anti-GnRH antibodies, was reduced (P less than .005) by 90% in ponies immunized against GnRH relative to ponies immunized against BSA. In contrast, the FSH response to GnRH analog was similar (P greater than .1) for both groups. Immunization against GnRH reduced (P less than .05) weight of the anterior pituitary (AP) by 31%, LH content in AP by 91% and FSH content in AP by 55% relative to ponies immunized against BSA. There was no effect of GnRH immunization on prolactin characteristics or on GnRH concentrations in the median eminence, preoptic area or body of the hypothalamus.(ABSTRACT TRUNCATED AT 250 WORDS)


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A Wagner and R Claus
Involvement of glucocorticoids in testicular involution after active immunization of boars against GnRH
Reproduction, February 1, 2004; 127(2): 275 - 283.
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Copyright © 1990 by the American Society of Animal Science.