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The Metabolism of ⁷⁵Se-Selenomethionine in Sheep Given Supplementary Copper and Molybdenum^1,2,

University of Wisconsin, Madison 53706

Abstract

Four groups of three ram lambs were fed, in group pens, the following diets from 4 to 19 wk of age: 1) control (6 mg Cu/kg and 1 mg Mo/kg); 2) control plus 10 mg Cu/kg; 3) control plus 10 mg Mo/kg and 4) control plus 10 mg/kg of both Cu and Mo. Copper and Mo were added to the diet as copper sulfate and sodium molybdate. The main ingredients of the diets were alfalfa hay (20%), oats (20%) and corn (59%). At 19 wk, the animals were allocated randomly to individual metabolism cages and received a single oral dose of ⁷⁵Se-selenomethionine. Liver Cu concentrations at slaughter (22 wk) were 77, 259, 68 and 316 mg/kg fresh weight for treatments 1 through 4. There was clinical evidence of Cu poisoning in lambs on treatment 2. Sheep given Cu supplements without additional Mo had reduced (P < .05) levels of ⁷⁵Se activity in muscle compared with control animals. This decrease in muscle ⁷⁵Se in Cu-supplemented lambs was associated with a nonsignificant increase in ⁷⁵Se content of other tissues and a nonsignificant increase in fecal excretion of ⁷⁵Se. Apparent absorption and net retention of ⁷⁵Se was 80% and 74%, respectively. Long-term ingestion of moderate levels of Cu influenced the metabolism of Se fed as selenomethionine, possibly through effects of chronic Cu toxicity on liver function.

¹ Research supported by College of Agric. and Life Sci., Univ. of Wisconsin.

² The authors are indebted to J. Elphic and R. Jensen of the research farm for their assistance in the feeding and care of the animals. C.L.W. is grateful for financial support from the Fulbright Fellowship and the Wisconsin Alumni Research Foundation. The authors thank Dr. Ribelin for the histological examination of the liver samples.

³ CSIRO, Private Bag, P.O. Wembley, Western Australia, 6014.

⁴ Present address: Lincoln County Extension, 1106 E 8th Street, Merrill, WI 54452.

⁵ Dept. of Biochem.

⁶ Dept. of Meat and Anim. Sci.