J. Anim Sci.
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J. Anim Sci. 1989. 67:2341-2346.
© 1989 American Society of Animal Science
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Evaluation of a Biological Response Modifier: Effects on Starter Pig Performance1

R. C. Thaler2, J. L. Nelssen3,4,, G. A. Anderson5, F. Blecha6, C. G. Chitko6, S. K. Chapes7 and E. R. Clough8

Kansas State University, Manhattan 66506

Abstract

The influence of a biological response modifier (FK-565) on weanling pig performance was evaluated. One hundred twenty-five weanling pigs (weaned at 21 ± 3 d) averaging 6.3 kg were utilized in a 35-d growth trial. Dietary treatments included a basal diet (1.25% lysine, corn-soybean meal-dried whey), the basal plus .1, 1 or 10 ppm FK-565 and the control plus an antibacterial combination containing chlortetracycline, sulfamethazine and penicillin. Performance was recorded weekly, and on d 35 all pigs were bled for whole blood and serum chemistry profiles and then were euthanatized. Heart, liver, kidneys and spleen weights were recorded. Also, gross and histological examinations were made of these organs, as well as sections of lung, ileum, bone marrow, thymus and mesenteric lymph node. By d 14, pigs fed the antibacterial diet gained faster (P < .06) than pigs fed the control and FK-565 diets. However, no differences (P > .10) in feed intake at d 14 or efficiency of feed utilization at either d 14 or 35 were observed. For the overall 35-d trial, ADG was greater (P < .01) for pigs consuming the antibacterial diet than for pigs consuming control and the FK-565 diets. Pigs consumed more of the antibacterial diet than of the other diets (P < .05). Most serum and whole blood criteria were unaffected by treatment; however, pigs receiving diets containing FK-565 exhibited higher neutrophil counts (P < .01), lower lymphocyte counts (P < .05) and greater concentrations of albumin (P < .05) than pigs not fed FK-565 diets. Gross and microscopic features of the organs examined were unaffected by dietary treatment, but FK-565 treatment quadratically decreased kidney weights (P < .05). At the concentrations investigated, FK-565 additions did not enhance starter pig performance.

Footnotes

1 Published as contribution no. 88-509-J from the Kansas Agric. Exp. Sta.

2 Present address: Dept. of Anim. and Range Sci., South Dakota State Univ., Brookings 57007.

3 Dept. of Anim. Sci. and Ind.

4 To whom reprint requests should be addressed.

5 Dept. of Vet. Sci., Univ. of Nebraska, Lincoln.

6 Dept. of Anat. and Physiol.

7 Div. of Biol.

8 Pitman-Moore IMC, Northbrook, IL.






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Copyright © 1989 by the American Society of Animal Science.